Long Survival and Preservation of Good Visual Acuity in a Patient with Bilateral Diffuse Uveal Melanocytic Proliferation.
Details
Serval ID
serval:BIB_54900418D973
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Long Survival and Preservation of Good Visual Acuity in a Patient with Bilateral Diffuse Uveal Melanocytic Proliferation.
Journal
Ocular oncology and pathology
ISSN
2296-4681 (Print)
ISSN-L
2296-4657
Publication state
Published
Issued date
01/2019
Peer-reviewed
Oui
Volume
5
Number
1
Pages
75-78
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
To report a patient with bilateral diffuse uveal melanocytic proliferation (BDUMP) due to a lung carcinoma, who survived 9.5 years with preservation of good visual acuity after cataract surgery and curative chemotherapy with neoadjuvant radiation therapy.
Clinical review of a patient with BDUMP.
We report the case of a 64-year-old man presenting with bilateral visual deterioration. Ophthalmological examination showed bilateral cataract, a small elevated non-pigmented tumor in the iris and multiple elevated, diffuse round pigmented choroidal lesions. Based on the clinical presentation, the diagnosis of BDUMP was suspected. After referral to an internal medicine specialist, a poorly differentiated non-small cell lung carcinoma was diagnosed and treated with chemotherapy followed by irradiation. After 3 years, spontaneous depigmentation of the choroidal lesions occurred. According to the literature, the mean survival of patients with BDUMP is 11.6 months. Our patient, however, survived for 9.5 years with preservation of good visual acuity after cataract extraction.
This case illustrates that prolonged survival and preservation of useful visual acuity is possible in BDUMP. Cataract surgery should be considered in selected patients, and depigmentation of the lesions may occur during long-term follow-up.
Clinical review of a patient with BDUMP.
We report the case of a 64-year-old man presenting with bilateral visual deterioration. Ophthalmological examination showed bilateral cataract, a small elevated non-pigmented tumor in the iris and multiple elevated, diffuse round pigmented choroidal lesions. Based on the clinical presentation, the diagnosis of BDUMP was suspected. After referral to an internal medicine specialist, a poorly differentiated non-small cell lung carcinoma was diagnosed and treated with chemotherapy followed by irradiation. After 3 years, spontaneous depigmentation of the choroidal lesions occurred. According to the literature, the mean survival of patients with BDUMP is 11.6 months. Our patient, however, survived for 9.5 years with preservation of good visual acuity after cataract extraction.
This case illustrates that prolonged survival and preservation of useful visual acuity is possible in BDUMP. Cataract surgery should be considered in selected patients, and depigmentation of the lesions may occur during long-term follow-up.
Keywords
Bilateral diffuse uveal melanocytic proliferation, Iris, Paraneoplastic syndrome, Uveal tumor
Pubmed
Web of science
Open Access
Yes
Create date
11/02/2020 10:15
Last modification date
26/02/2024 16:45