The European/International Fibromuscular Dysplasia Registry and Initiative (FEIRI)-clinical phenotypes and their predictors based on a cohort of 1000 patients.
Details
Serval ID
serval:BIB_548DD62AB8B5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The European/International Fibromuscular Dysplasia Registry and Initiative (FEIRI)-clinical phenotypes and their predictors based on a cohort of 1000 patients.
Journal
Cardiovascular research
Working group(s)
European/International FMD Registry and Initiative (FEIRI), and the Working Group ‘Hypertension and the Kidney' of the European Society of Hypertension (ESH)
Contributor(s)
Aparicio L.S., Persu A., Pappaccogli M., Beauloye C., Chenu P., Hammer F., Goffette P., Astarci P., Peeters A., Verhelst R., Vikkula M., Van der Niepen P., Van Tussenbroek F., De Backer T., Gevaert S., Hemelsoet D., Defreyne L., Heuten H., Yperzeele L., Van der Zijden T., Lengelé J.P., Krzesinski J.M., Sprynger M., Delmotte P., Verhamme P., Vanassche T., Scoppettuolo P., Wautrecht J.C., Vinck W., Dobrin V., Teodora Y., Wang J., Xu J., Jelaković B., Dika Z., Gordin D., Tikkanen I., Venermo M., Mäkelä R.N., Plouin P.F., Jeunemaitre X., Toubiana L., Azizi M., Amar L., Chédid A., Mousseaux E., Lorthioir A., Ormezzano O., Seinturier C., Thony F., Mahfoud F., Kulenthiran S., Sarafidis P., Piperidou A., Doumas M., Stergiou G.S., Vlahakos D., Canning C., Sharabi Y., Morganti A., Bruno R.M., Taddei S., Romanini C., Petrucci I., Rabbia F., Pappaccogli M., Di Monaco S., Rossi G.P., Lerco S., Minuz P., Mansueto G., De Marchi S., Marcon D., Salice P., Visonà A., Bigolin P., Zingaretti V., Cianci R., Zedde M., Matteucci M.C., Iwashima Y., Kawarada O., Kadoya Y., van Twist D.J., Kroon B., de Leeuw P., Spiering W., van den Born B.J., Høieggen A., Sommer M.S., Januszewicz A., Warchoł-Celińska E., Prejbisz A., Witkowski A., Witowicz H., Kądziela J., Soplińska A., Pieluszczak K., Jóżwik-Plebanek K., Januszewicz M., Florczak E., Dobrowolski P., Szabóová E., Hudák M., Moščovič M., Mediavilla J.D., Aguila F.J., Oliveras A., Segura J., Prado J.C., Robles N.R., Poch E., Montagud-Marrahi E., Molina A., Guillen E., Burrel M., De la Llama P.F., Barros-Membrilla A.J., Gottsäter A., Wuerzner G., Mazzolai L., Buso G., Jarraya F., Chaker H., Adlam D., Chrysochou C., Dhaun N., Hunter R.W., MacIntyre I., Webb D.
ISSN
1755-3245 (Electronic)
ISSN-L
0008-6363
Publication state
Published
Issued date
22/02/2021
Peer-reviewed
Oui
Volume
117
Number
3
Pages
950-959
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Since December 2015, the European/International Fibromuscular Dysplasia (FMD) Registry enrolled 1022 patients from 22 countries. We present their characteristics according to disease subtype, age and gender, as well as predictors of widespread disease, aneurysms and dissections.
All patients diagnosed with FMD (string-of-beads or focal stenosis in at least one vascular bed) based on computed tomography angiography, magnetic resonance angiography, and/or catheter-based angiography were eligible. Patients were predominantly women (82%) and Caucasians (88%). Age at diagnosis was 46 ± 16 years (12% ≥65 years old), 86% were hypertensive, 72% had multifocal, and 57% multivessel FMD. Compared to patients with multifocal FMD, patients with focal FMD were younger, more often men, had less often multivessel FMD but more revascularizations. Compared to women with FMD, men were younger, had more often focal FMD and arterial dissections. Compared to younger patients with FMD, patients ≥65 years old had more often multifocal FMD, lower estimated glomerular filtration rate and more atherosclerotic lesions. Independent predictors of multivessel FMD were age at FMD diagnosis, stroke, multifocal subtype, presence of aneurysm or dissection, and family history of FMD. Predictors of aneurysms were multivessel and multifocal FMD. Predictors of dissections were age at FMD diagnosis, male gender, stroke, and multivessel FMD.
The European/International FMD Registry allowed large-scale characterization of distinct profiles of patients with FMD and, more importantly, identification of a unique set of independent predictors of widespread disease, aneurysms and dissections, paving the way for targeted screening, management, and follow-up of FMD.
All patients diagnosed with FMD (string-of-beads or focal stenosis in at least one vascular bed) based on computed tomography angiography, magnetic resonance angiography, and/or catheter-based angiography were eligible. Patients were predominantly women (82%) and Caucasians (88%). Age at diagnosis was 46 ± 16 years (12% ≥65 years old), 86% were hypertensive, 72% had multifocal, and 57% multivessel FMD. Compared to patients with multifocal FMD, patients with focal FMD were younger, more often men, had less often multivessel FMD but more revascularizations. Compared to women with FMD, men were younger, had more often focal FMD and arterial dissections. Compared to younger patients with FMD, patients ≥65 years old had more often multifocal FMD, lower estimated glomerular filtration rate and more atherosclerotic lesions. Independent predictors of multivessel FMD were age at FMD diagnosis, stroke, multifocal subtype, presence of aneurysm or dissection, and family history of FMD. Predictors of aneurysms were multivessel and multifocal FMD. Predictors of dissections were age at FMD diagnosis, male gender, stroke, and multivessel FMD.
The European/International FMD Registry allowed large-scale characterization of distinct profiles of patients with FMD and, more importantly, identification of a unique set of independent predictors of widespread disease, aneurysms and dissections, paving the way for targeted screening, management, and follow-up of FMD.
Keywords
Fibromuscular dysplasia, aneurysm, dissection, renovascular hypertension, stroke, Aneurysm, Dissection, Renovascular hypertension, Stroke
Pubmed
Web of science
Create date
25/04/2020 20:05
Last modification date
08/05/2021 5:32
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