A single dose of the SARS-CoV-2 vaccine BNT162b2 elicits Fc-mediated antibody effector functions and T cell responses.

Details

Serval ID
serval:BIB_5472E8A18937
Type
Article: article from journal or magazin.
Collection
Publications
Title
A single dose of the SARS-CoV-2 vaccine BNT162b2 elicits Fc-mediated antibody effector functions and T cell responses.
Journal
Cell host & microbe
Author(s)
Tauzin A., Nayrac M., Benlarbi M., Gong S.Y., Gasser R., Beaudoin-Bussières G., Brassard N., Laumaea A., Vézina D., Prévost J., Anand S.P., Bourassa C., Gendron-Lepage G., Medjahed H., Goyette G., Niessl J., Tastet O., Gokool L., Morrisseau C., Arlotto P., Stamatatos L., McGuire A.T., Larochelle C., Uchil P., Lu M., Mothes W., De Serres G., Moreira S., Roger M., Richard J., Martel-Laferrière V., Duerr R., Tremblay C., Kaufmann D.E., Finzi A.
ISSN
1934-6069 (Electronic)
ISSN-L
1931-3128
Publication state
Published
Issued date
14/07/2021
Peer-reviewed
Oui
Volume
29
Number
7
Pages
1137-1150.e6
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
While the standard regimen of the BNT162b2 mRNA vaccine for SARS-CoV-2 includes two doses administered 3 weeks apart, some public health authorities are spacing these doses, raising concerns about efficacy. However, data indicate that a single dose can be up to 90% effective starting 14 days post-administration. To assess the mechanisms contributing to protection, we analyzed humoral and T cell responses three weeks after a single BNT162b2 dose. We observed weak neutralizing activity elicited in SARS-CoV-2 naive individuals but strong anti-receptor binding domain and spike antibodies with Fc-mediated effector functions and cellular CD4 <sup>+</sup> T cell responses. In previously infected individuals, a single dose boosted all humoral and T cell responses, with strong correlations between T helper and antibody immunity. Our results highlight the potential role of Fc-mediated effector functions and T cell responses in vaccine efficacy. They also provide support for spacing doses to vaccinate more individuals in conditions of vaccine scarcity.
Keywords
Adult, Antibodies, Neutralizing/immunology, Antibodies, Viral/chemistry, Antibodies, Viral/immunology, BNT162 Vaccine, Betacoronavirus, COVID-19/immunology, COVID-19/prevention & control, COVID-19 Vaccines/administration & dosage, COVID-19 Vaccines/immunology, Carrier Proteins, Female, Humans, Immunity, Immunoglobulin Fc Fragments, Male, Middle Aged, SARS-CoV-2/immunology, T-Lymphocytes/immunology, Vaccination, Vaccines, Synthetic/immunology, Young Adult, mRNA Vaccines, ADCC, COVID-19, SARS-CoV-2, T cell responses, coronavirus, humoral responses, mRNA vaccine, neutralization, spike glycoproteins, variants
Pubmed
Web of science
Open Access
Yes
Create date
09/05/2023 12:59
Last modification date
29/11/2024 13:39
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