Phactr2 and Parkinson's disease.

Details

Serval ID
serval:BIB_54697BEC6343
Type
Article: article from journal or magazin.
Collection
Publications
Title
Phactr2 and Parkinson's disease.
Journal
Neuroscience Letters
Author(s)
Wider C., Lincoln S.J., Heckman M.G., Diehl N.N., Stone J.T., Haugarvoll K., Aasly J.O., Gibson J.M., Lynch T., Rajput A., Rajput M.L., Uitti R.J., Wszolek Z.K., Farrer M.J., Ross O.A.
ISSN
0304-3940[print], 0304-3940[linking]
Publication state
Published
Issued date
2009
Volume
453
Number
1
Pages
9-11
Language
english
Abstract
Attempts at replicating the first genome-wide association study (GWAS) in Parkinson's disease (PD) have not successfully identified genetic risk factors. The present study reevaluates data from the first GWAS and focuses on the SNP (rs11155313, located in the Phactr2 gene) with the lowest P-value in the Tier 2 patient-control series. We employed four case-control series to examine the nominated SNP rs11155313 and identified association in US (OR: 1.39, P=0.032), Canadian (OR: 1.41, P=0.014) and Irish (OR: 1.44, P=0.034) patient-control series, but not in the Norwegian series (OR: 1.15, P=0.27). When combining all four series the observed trend was statistically significant (OR: 1.30, P<0.001). This study shows that reappraisal of publicly available results of GWAS may help nominate new risk factors for PD.
Keywords
Adolescent, Adult, Aged, Aged, 80 and over, Canada/epidemiology, Case-Control Studies, Female, Gene Frequency, Genome-Wide Association Study, Genotype, Humans, Ireland/epidemiology, Male, Microfilament Proteins/genetics, Middle Aged, Nerve Tissue Proteins/genetics, Norway/epidemiology, Parkinson Disease/epidemiology, Parkinson Disease/genetics, Polymorphism, Single Nucleotide, Risk Factors, United States/epidemiology, Young Adult
Pubmed
Create date
24/09/2010 19:05
Last modification date
20/08/2019 15:09
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