Crosstalk and spatiotemporal regulation between stress-induced MAP kinase pathways and pheromone signaling in budding yeast.

Details

Serval ID
serval:BIB_543FEFBD8145
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Crosstalk and spatiotemporal regulation between stress-induced MAP kinase pathways and pheromone signaling in budding yeast.
Journal
Cell cycle
Author(s)
Van Drogen F., Dard N., Pelet S., Lee S.S., Mishra R., Srejić N., Peter M.
ISSN
1551-4005 (Electronic)
ISSN-L
1551-4005
Publication state
Published
Issued date
07/2020
Peer-reviewed
Oui
Volume
19
Number
14
Pages
1707-1715
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Budding yeast, Saccharomyces cerevisiae, has been widely used as a model system to study cellular signaling in response to internal and external cues. Yeast was among the first organisms in which the architecture, feedback mechanisms and physiological responses of various MAP kinase signaling cascades were studied in detail. Although these MAP kinase pathways are activated by different signals and elicit diverse cellular responses, such as adaptation to stress and mating, they function as an interconnected signaling network, as they influence each other and, in some cases, even share components. Indeed, various stress signaling pathways interfere with pheromone signaling that triggers a distinct cellular differentiation program. However, the molecular mechanisms responsible for this crosstalk are still poorly understood. Here, we review the general topology of the yeast MAP kinase signaling network and highlight recent and new data revealing how conflicting intrinsic and extrinsic signals are interpreted to orchestrate appropriate cellular responses.
Keywords
Yeast MAP kinase signaling, crosstalk
Pubmed
Web of science
Create date
06/07/2020 14:28
Last modification date
17/02/2021 7:27
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