A focus on yeast mating: From pheromone signaling to cell-cell fusion.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_5438E395CE11
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
A focus on yeast mating: From pheromone signaling to cell-cell fusion.
Journal
Seminars in cell & developmental biology
Author(s)
Sieber B., Coronas-Serna J.M., Martin S.G.
ISSN
1096-3634 (Electronic)
ISSN-L
1084-9521
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: aheadofprint
Abstract
Cells live in a chemical environment and are able to orient towards chemical cues. Unicellular haploid fungal cells communicate by secreting pheromones to reproduce sexually. In the yeast models Saccharomyces cerevisiae and Schizosaccharomyces pombe, pheromonal communication activates similar pathways composed of cognate G-protein-coupled receptors and downstream small GTPase Cdc42 and MAP kinase cascades. Local pheromone release and sensing, at a mobile surface polarity patch, underlie spatial gradient interpretation to form pairs between two cells of distinct mating types. Concentration of secretion at the point of cell-cell contact then leads to local cell wall digestion for cell fusion, forming a diploid zygote that prevents further fusion attempts. A number of asymmetries between mating types may promote efficiency of the system. In this review, we present our current knowledge of pheromone signaling in the two model yeasts, with an emphasis on how cells decode the pheromone signal spatially and ultimately fuse together. Though overall pathway architectures are similar in the two species, their large evolutionary distance allows to explore how conceptually similar solutions to a general biological problem can arise from divergent molecular components.
Keywords
Cdc42 GTPase, Cell fusion, Chemotropism, MAPK signaling, Mating, Pheromone signaling
Pubmed
Open Access
Yes
Create date
19/02/2022 12:34
Last modification date
01/03/2022 8:09
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