Non-Hodgkin Lymphomas: Pathology and Genetics

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State: Public
Version: Final published version
License: All rights reserved
Serval ID
serval:BIB_5432C7E5C88E
Type
A part of a book
Publication sub-type
Chapter: chapter ou part
Collection
Publications
Institution
Title
Non-Hodgkin Lymphomas: Pathology and Genetics
Title of the book
Encyclopedia of Cancer
Author(s)
de Leval L.
Publisher
Elsevier
ISBN
9780128012383
Publication state
Published
Issued date
2018
Series
Reference Module in Biomedical Sciences
Pages
48-75
Edition
3rd ed.
Language
english
Abstract
Non-Hodgkin lymphomas (NHL), the 6th most frequent cancer in western countries, represent a large group of clonal proliferations derived from lymphoid cells. With available techniques, a large number of clinically and biologically distinct tumors are listed in the World Health Organization (WHO) classification. Disease definition is based on morphology, immunophenotype, genetic and molecular features, viral associations in certain cases, clinical characteristics and if possible the normal cell counterpart, which is an important determinant of lymphoma biology. Lymphomas derived from B-cells are by far most frequent, and NK/T-cell NHL account for < 10% of the cases. Recent technological and analytical advances in genetic, epigenetic and molecular profiling methods and next-generation sequencing technologies have markedly accelerated the characterization of lymphoma-associated molecular signatures and genetic profiles, and the discovery of genetic lesions, which collectively have greatly enhanced our understanding of lymphoma pathogenesis and are relevant to defining optimal therapies.
Keywords
Angioimmunoblastic T-cell lymphoma, Cell of origin, Chronic lymphocytic leukemia, Diffuse large B-cell lymphoma, Follicular lymphoma, Gene expression profiling, GeneticsMarginal zone lymphoma, MutationNon-Hodgkin lymphoma, Pathogenesis, Pathology, Peripheral T-cell lymphoma, Translocation, World Health Organization classification
Create date
23/11/2018 9:43
Last modification date
11/09/2020 6:22
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