Effets indésirables des inhibiteurs de points de contrôle immunitaire : diagnostic et prise en charge [Side effects of immune checkpoint inhibitors: diagnosis and management]

Details

Serval ID
serval:BIB_542B193CD99A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Effets indésirables des inhibiteurs de points de contrôle immunitaire : diagnostic et prise en charge [Side effects of immune checkpoint inhibitors: diagnosis and management]
Journal
Revue medicale suisse
Author(s)
Perrinjaquet C., Zaher M., Ferraro D.A., Comte D., Trueb L., Zimmermann S., Coukos G., Orcurto A.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
15/05/2019
Peer-reviewed
Oui
Volume
15
Number
651
Pages
1010-1016
Language
french
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
New oncological approaches using immune checkpoint inhibitors aim to reinvigorate lymphocytes against the tumor. The prognosis of cancer has been significantly improved by these treatments, which nonetheless lead to a new spectrum of immune-related side effects. The most frequent are skin rash, colitis, thyroid dysfunction, hypophysitis, hepatitis and pneumonitis. Early detection of these toxicities is crucial to determine the etiology and to introduce a temporary immunosuppressive therapy, allowing resolution of toxicity in most of cases. A multidisciplinary team is essential for optimal management.
Keywords
Antibodies, Monoclonal, Drug-Related Side Effects and Adverse Reactions, Humans, Immunologic Factors/adverse effects, Neoplasms/therapy, Pneumonia/chemically induced
Pubmed
Create date
21/05/2019 8:30
Last modification date
06/03/2020 7:20
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