Haematopoietic stem cell niche in Drosophila

Details

Serval ID
serval:BIB_5410DD7DEBE4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Haematopoietic stem cell niche in Drosophila
Journal
Bioessays
Author(s)
Koch  U., Radtke  F.
ISSN
0265-9247 (Print)
Publication state
Published
Issued date
08/2007
Volume
29
Number
8
Pages
713-6
Notes
Journal Article
Review --- Old month value: Aug
Abstract
Development and homeostasis of the haematopoietic system is dependent upon stem cells that have the unique ability to both self-renew and to differentiate in all cell lineages of the blood. The crucial decision between haematopoietic stem cell (HSC) self-renewal and differentiation must be tightly controlled. Ultimately, this choice is regulated by the integration of intrinsic signals together with extrinsic cues provided by an exclusive microenvironment, the so-called haematopoietic niche. Although the haematopoietic system of vertebrates has been studied extensively for many decades, the specification of the HSC niche and its signals involved are poorly understood. Much of our current knowledge of how niches regulate long-term maintenance of stem cells is derived from studies on Drosophila germ cells. Now, two recently published studies by Mandal et al.1 and Krezmien et al.2 describe the Drosophila haematopoietic niche and signal transduction pathways that are involved in the maintenance of haematopoietic precursors. Both reports emphasize several features that are important for controlling stem cell behavior and show parallels to both the vertebrate haematopoietic niche as well as the Drosophila germline stem cell niches in ovary and testis. The findings of both papers shed new light on the specific interactions between haematopoietic progenitors and their microenvironment.
Keywords
Animals Drosophila/*physiology Embryo, Nonmammalian Hematopoietic Stem Cells/*physiology Hemolymph/cytology/metabolism Models, Biological
Pubmed
Web of science
Create date
28/01/2008 11:39
Last modification date
20/08/2019 14:09
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