Antibiotic-driven dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates allergic airway inflammation in adulthood.

Details

Serval ID
serval:BIB_540ED9A82B4C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Antibiotic-driven dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates allergic airway inflammation in adulthood.
Journal
Immunity
Author(s)
Perdijk O., Butler A., Macowan M., Chatzis R., Bulanda E., Grant R.D., Harris N.L., Wypych T.P., Marsland B.J.
ISSN
1097-4180 (Electronic)
ISSN-L
1074-7613
Publication state
Published
Issued date
13/08/2024
Peer-reviewed
Oui
Volume
57
Number
8
Pages
1939-1954.e7
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Antibiotic use in early life disrupts microbial colonization and increases the risk of developing allergies and asthma. We report that mice given antibiotics in early life (EL-Abx), but not in adulthood, were more susceptible to house dust mite (HDM)-induced allergic airway inflammation. This susceptibility was maintained even after normalization of the gut microbiome. EL-Abx decreased systemic levels of indole-3-propionic acid (IPA), which induced long-term changes to cellular stress, metabolism, and mitochondrial respiration in the lung epithelium. IPA reduced mitochondrial respiration and superoxide production and altered chemokine and cytokine production. Consequently, early-life IPA supplementation protected EL-Abx mice against exacerbated HDM-induced allergic airway inflammation in adulthood. These results reveal a mechanism through which EL-Abx can predispose the lung to allergic airway inflammation and highlight a possible preventative approach to mitigate the detrimental consequences of EL-Abx.
Keywords
Animals, Mice, Dysbiosis/immunology, Indoles/pharmacology, Anti-Bacterial Agents/adverse effects, Anti-Bacterial Agents/pharmacology, Gastrointestinal Microbiome/drug effects, Gastrointestinal Microbiome/immunology, Asthma/immunology, Pyroglyphidae/immunology, Lung/immunology, Lung/pathology, Mice, Inbred C57BL, Female, Inflammation/immunology, Disease Models, Animal, Mitochondria/metabolism, Cytokines/metabolism, Hypersensitivity/immunology, Propionates, airway epithelial cells, allergy, antibiotics, early life, gut-lung axis, indole-3-propionic acid, metabolites, microbiota, redox balance, window of opportunity
Pubmed
Web of science
Create date
19/07/2024 10:25
Last modification date
11/09/2024 6:21
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