Protection From Varicella Zoster in Solid Organ Transplant Recipients Carrying Killer Cell Immunoglobulin-Like Receptor B Haplotypes.
Details
Serval ID
serval:BIB_53EDE710E344
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Protection From Varicella Zoster in Solid Organ Transplant Recipients Carrying Killer Cell Immunoglobulin-Like Receptor B Haplotypes.
Journal
Transplantation
Working group(s)
Swiss Transplant Cohort Study
Contributor(s)
Achermann R., Aubert JD., Baumann P., Beldi G., Benden C., Berger C., Berney T., Binet I., Bochud PY., Boely E., Bucher H., Bühler L., Carell T., Catana E., Chalandon Y., de Geest S., de Rougemont O., Dickenmann M., Duchosal M., Fehr T., Ferrari-Lacraz S., Garzoni C., Gasche Y., Soccal PG., Giostra E., Golshayan D., Good D., Hadaya K., Hess C., Hillinger S., Hirsch H., Hofbauer G., Huynh-Do U., Immer F., Klaghofer R., Koller M., Kuntzen T., Laesser B., Lehmann R., Lovis C., Manuel O., Marti HP., Martin PY., Meylan P., Mohacsi P., Morard I., Morel P., Mueller U., Mueller N., Mueller-McKenna H., Müller T., Müllhaupt B., Nadal D., Nair G., Pascual M., Passweg J., Ziegler CP., Rick J., Roosnek E., Rosselet A., Rothlin S., Ruschitzka F., Schanz U., Schaub S., Seiler C., Semmo N., Stampf S., Steiger J., Tsinalis D., Van Delden C., Venetz JP., Villard J., Wick M., Wilhlem M., Yerly P.
ISSN
1534-6080 (Electronic)
ISSN-L
0041-1337
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
99
Number
12
Pages
2651-2655
Language
english
Abstract
BACKGROUND: Natural killer cell function is regulated by inhibitory and activating killer cell immunoglobulin-like receptors (KIR). Previous studies have documented associations of KIR genotype with the risk of cytomegalovirus (CMV) replication after solid organ transplantation.
METHODS: In this study of 649 solid organ transplant recipients, followed prospectively for infectious disease events within the Swiss Transplant Cohort Study, we were interested to see if KIR genotype associated with virus infections other than CMV.
RESULT: We found that KIR B haplotypes (which have previously been linked to protection from CMV replication) were associated with protection from varicella zoster virus infection (hazard ratio, 0.43; 95% confidence interval, 0.21-0.91; P = 0.03). No significant associations were detected regarding the risk of herpes simplex, Epstein-Barr virus or BK polyomavirus infections.
CONCLUSIONS: In conclusion, these data provide evidence that the relative protection of KIR haplotype B from viral replication after solid organ transplantation may extend beyond CMV to other herpes viruses, such as varicella zoster virus and possibly Epstein-Barr virus.
METHODS: In this study of 649 solid organ transplant recipients, followed prospectively for infectious disease events within the Swiss Transplant Cohort Study, we were interested to see if KIR genotype associated with virus infections other than CMV.
RESULT: We found that KIR B haplotypes (which have previously been linked to protection from CMV replication) were associated with protection from varicella zoster virus infection (hazard ratio, 0.43; 95% confidence interval, 0.21-0.91; P = 0.03). No significant associations were detected regarding the risk of herpes simplex, Epstein-Barr virus or BK polyomavirus infections.
CONCLUSIONS: In conclusion, these data provide evidence that the relative protection of KIR haplotype B from viral replication after solid organ transplantation may extend beyond CMV to other herpes viruses, such as varicella zoster virus and possibly Epstein-Barr virus.
Keywords
Adolescent, Adult, Aged, Chickenpox/prevention & control, Chickenpox/virology, Child, Child, Preschool, Female, Follow-Up Studies, Graft Rejection/immunology, Graft Rejection/prevention & control, Haplotypes, Herpesvirus 3, Human/genetics, Humans, Infant, Infant, Newborn, Kidney Transplantation, Male, Middle Aged, Receptors, KIR/genetics, Retrospective Studies, Transplant Recipients, Virus Replication/genetics, Young Adult
Pubmed
Web of science
Create date
01/03/2016 19:35
Last modification date
27/01/2024 8:36
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