Improving Pleasure and Motivation in Schizophrenia: A Randomized Controlled Clinical Trial.

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License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_53DCAB64149F
Type
Article: article from journal or magazin.
Collection
Publications
Title
Improving Pleasure and Motivation in Schizophrenia: A Randomized Controlled Clinical Trial.
Journal
Psychotherapy and psychosomatics
Author(s)
Favrod J., Nguyen A., Chaix J., Pellet J., Frobert L., Fankhauser C., Ismailaj A., Brana A., Tamic G., Suter C., Rexhaj S., Golay P., Bonsack C.
ISSN
1423-0348 (Electronic)
ISSN-L
0033-3190
Publication state
Published
Issued date
2019
Peer-reviewed
Oui
Volume
88
Number
2
Pages
84-95
Language
english
Notes
Publication types: Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Negative symptoms are frequent in patients with schizophrenia and are associated with marked impairments in social functioning. The efficacy of drug-based treatments and psychological interventions on primary negative symptoms remains limited. The Positive Emotions Programme for Schizophrenia (PEPS) is designed to improve pleasure and motivation in schizophrenia patients by targeting emotion regulation and cognitive skills relevant to apathy and anhedonia. The main hypothesis of this study is that patients who attend 8 one-hour sessions of PEPS and treatment as usual (TAU) will have lower total apathy-avolition and anhedonia-asociality composite scores on the Scale for the Assessment of Negative Symptoms (SANS) than patients who attend only TAU.
Eighty participants diagnosed with schizophrenia or schizoaffective disorder were randomized to receive either TAU or PEPS + TAU. The participants were assessed by independent evaluators before randomization (T0), in a post-test after 8 weeks of treatment (T1) and at a 6-month follow-up (T2).
The post-test results and 6-month follow-up assessments according to an intention-to-treat analysis showed that the apathy and anhedonia composite scores on the SANS indicated statistically greater clinical improvements in PEPS participants than in non-PEPS participants. In the post-test, anhedonia but not apathy was significantly improved, thus favouring the PEPS condition. These results were sustained at the 6-month follow-up.
PEPS is an effective intervention to reduce anhedonia in schizophrenia. PEPS is a short, easy-to-use, group-based, freely available intervention that is easy to implement in a variety of environments (ClinicalTrials.gov ID: NCT02593058).
Keywords
Adult, Anhedonia, Apathy, Cognitive Behavioral Therapy, Female, Humans, Male, Motivation, Pleasure, Psychiatric Status Rating Scales, Schizophrenia/complications, Schizophrenia/therapy, Schizophrenic Psychology, Treatment Outcome, Negative symptoms, Positive psychology, Randomized controlled trial, Schizophrenia
Pubmed
Web of science
Open Access
Yes
Create date
30/12/2018 20:55
Last modification date
20/08/2019 15:08
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