Endocarditis prophylaxis: from experimental models to human recommendation

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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_53A932113477
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Endocarditis prophylaxis: from experimental models to human recommendation
Journal
European Heart Journal
Author(s)
Blatter  M., Francioli  P.
ISSN
0195-668X (Print)
Publication state
Published
Issued date
04/1995
Volume
16 Suppl B
Pages
107-9
Language
english
Notes
Journal Article
Review --- Old month value: Apr
licence nationale
Abstract
Animal models of endocarditis have helped understanding of the mode of action of antibiotics in prophylaxis. During bacteraemia, some microorganisms will adhere to damaged cardiac valves. The proportion of bacteria that will adhere depends largely on intrinsic properties of the strain. In the absence of antibiotics, the microorganisms will either be eliminated by local host defence mechanisms if the inoculum is low enough or will begin to grow approximately 2 h after the development of bacteraemia and endocarditis. In the presence of antibiotics, the growth of adherent bacteria is inhibited and local host defences have longer to eliminate the bacteria. In cases where the number of adherent bacteria is relatively low, a short period in inhibitory antibiotic activity (6 hours) is sufficient to eliminate the bacteria and lead to successful prophylaxis. If the number of bacteria is high, a longer duration of the inhibitory effect is necessary. These experimental data provide a rationale for practical recommendations for the prophylaxis of endocarditis in humans.
Keywords
Animals Anti-Bacterial Agents/pharmacology/*therapeutic use Bacteria/drug effects Disease Models, Animal Endocarditis, Bacterial/microbiology/*prevention & control Humans Risk Factors
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 18:08
Last modification date
01/10/2019 7:17
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