Macroautophagy and normal aging of the nervous system: Lessons from animal models.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_539B8E66988A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Macroautophagy and normal aging of the nervous system: Lessons from animal models.
Journal
Cell stress
Author(s)
Kallergi E., Nikoletopoulou V.
ISSN
2523-0204 (Electronic)
ISSN-L
2523-0204
Publication state
Published
Issued date
10/2021
Peer-reviewed
Oui
Volume
5
Number
10
Pages
146-166
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Aging represents a cumulative form of cellular stress, which is thought to challenge many aspects of proteostasis. The non-dividing, long-lived neurons are particularly vulnerable to stress, and, not surprisingly, even normal aging is highly associated with a decline in brain function in humans, as well as in other animals. Macroautophagy is a fundamental arm of the proteostasis network, safeguarding proper protein turnover during different cellular states and against diverse cellular stressors. An intricate interplay between macroautophagy and aging is beginning to unravel, with the emergence of new tools, including those for monitoring autophagy in cultured neurons and in the nervous system of different organisms in vivo. Here, we review recent findings on the impact of aging on neuronal integrity and on neuronal macroautophagy, as they emerge from studies in invertebrate and mammalian models.
Keywords
aging, macroautophagy, nervous system, proteostasis
Pubmed
Web of science
Open Access
Yes
Create date
01/11/2021 10:41
Last modification date
10/11/2021 6:39
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