Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass but not after gastric lap-band in mice.

Details

Serval ID
serval:BIB_5363474544E9
Type
Article: article from journal or magazin.
Collection
Publications
Title
Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass but not after gastric lap-band in mice.
Journal
Cell Metabolism
Author(s)
Troy S., Soty M., Ribeiro L., Laval L., Migrenne S., Fioramonti X., Pillot B., Fauveau V., Aubert R., Viollet B., Foretz M., Leclerc J., Duchampt A., Zitoun C., Thorens B., Magnan C., Mithieux G., Andreelli F.
ISSN
1932-7420 (Electronic)
ISSN-L
1550-4131
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
8
Number
3
Pages
201-211
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Unlike the adjustable gastric banding procedure (AGB), Roux-en-Y gastric bypass surgery (RYGBP) in humans has an intriguing effect: a rapid and substantial control of type 2 diabetes mellitus (T2DM). We performed gastric lap-band (GLB) and entero-gastro anastomosis (EGA) procedures in C57Bl6 mice that were fed a high-fat diet. The EGA procedure specifically reduced food intake and increased insulin sensitivity as measured by endogenous glucose production. Intestinal gluconeogenesis increased after the EGA procedure, but not after gastric banding. All EGA effects were abolished in GLUT-2 knockout mice and in mice with portal vein denervation. We thus provide mechanistic evidence that the beneficial effects of the EGA procedure on food intake and glucose homeostasis involve intestinal gluconeogenesis and its detection via a GLUT-2 and hepatoportal sensor pathway.
Keywords
Animals, Dietary Fats/administration & dosage, Eating, Gastric Bypass, Gastroplasty, Gluconeogenesis, Glucose/metabolism, Glucose Transporter Type 1/deficiency, Glucose Transporter Type 2/deficiency, Insulin/blood, Insulin Resistance, Intestine, Small/metabolism, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Models, Biological, Obesity, Morbid/metabolism, Obesity, Morbid/surgery, Portal Vein/metabolism, Reproducibility of Results, Time Factors
Pubmed
Web of science
Open Access
Yes
Create date
18/06/2009 15:04
Last modification date
20/08/2019 15:08
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