Invasive bladder carcinoma: a pilot study of conservative treatment with accelerated radiotherapy and concomitant cisplatin.

Details

Serval ID
serval:BIB_53397E8B26E6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Invasive bladder carcinoma: a pilot study of conservative treatment with accelerated radiotherapy and concomitant cisplatin.
Journal
International journal of cancer. Journal international du cancer
Author(s)
Zouhair A., Ozsahin M., Schneider D., Bauer J., Jichlinski P., Roth A., Douglas P., Miralbell R.
ISSN
0020-7136
Publication state
Published
Issued date
2001
Peer-reviewed
Oui
Volume
96
Number
6
Pages
350-5
Language
english
Notes
Publication types: Journal Article - Publication Status: ppublish
Abstract
From November 1992 to December 1997, 25 patients (inoperable or refusing cystectomy) were included in a prospective study to assess the feasibility, tolerance, and curative potential of accelerated radiotherapy (RT) and concomitant cisplatin. Median age was 74 years (range 49-86). Stage distribution was as follows: 1 T1, 10 T2, 8 T3, and 6 T4. Two patients had clinically positive pelvic nodes. The goal was to deliver a total dose of 40 Gy to the whole pelvis and bladder in 4 weeks using a concomitant boost of 20 Gy to the tumor or to the whole bladder during the third and fourth weeks (total dose 60 Gy), with daily cisplatin (6 mg/m(2)) before RT for patients with creatinine clearance > 50 ml/min. All but one patient completed the RT protocol. Daily cisplatin was successfully delivered in 18 patients. One patient presented with grade III ototoxicity. Diarrhea was scored grade III in two and grade IV in two patients. Acute urinary toxicity was scored grade III in one patient. Posttreatment late effects included bladder grade II and grade III in two patients and one patient, respectively; large bowel grade III in one; urethral grade III in one; and femoral head radionecrosis in one. Four-year overall and disease-specific survival rates were 23% and 35%, respectively. The latter was 60% for patients with T2 tumors. The 4-year actuarial locoregional control rate for all patients was 61%. In summary, accelerated RT and concomitant cisplatin is feasible with acceptable tolerance even in relatively old patients. Although outcome was better for patients with low-stage tumors, local control and survival rates appeared similar to those of standard RT schedules for a similar patient population.
Keywords
Aged, Aged, 80 and over, Antineoplastic Agents, Cisplatin, Combined Modality Therapy, Female, Humans, Male, Middle Aged, Pilot Projects, Prospective Studies, Survival Rate, Urinary Bladder Neoplasms
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 16:09
Last modification date
20/08/2019 14:08
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