Towards adaptive deep brain stimulation: clinical and technical notes on a novel commercial device for chronic brain sensing.

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Version: Final published version
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Serval ID
serval:BIB_531C440A593D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Towards adaptive deep brain stimulation: clinical and technical notes on a novel commercial device for chronic brain sensing.
Journal
Journal of neural engineering
Author(s)
Thenaisie Y., Palmisano C., Canessa A., Keulen B.J., Capetian P., Jiménez M.C., Bally J.F., Manferlotti E., Beccaria L., Zutt R., Courtine G., Bloch J., van der Gaag N.A., Hoffmann C.F., Moraud E.M., Isaias I.U., Contarino M.F.
ISSN
1741-2552 (Electronic)
ISSN-L
1741-2552
Publication state
Published
Issued date
31/08/2021
Peer-reviewed
Oui
Volume
18
Number
4
Pages
042002
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: epublish
Abstract
Objective. Technical advances in deep brain stimulation (DBS) are crucial to improve therapeutic efficacy and battery life. We report the potentialities and pitfalls of one of the first commercially available devices capable of recording brain local field potentials (LFPs) from the implanted DBS leads, chronically and during stimulation. The aim was to provide clinicians with well-grounded tips on how to maximize the capabilities of this novel device, both in everyday practice and for research purposes.Approach. We collected clinical and neurophysiological data of the first 20 patients (14 with Parkinson's disease (PD), five with dystonia, one with chronic pain) that received the Percept™ PC in our centres. We also performed tests in a saline bath to validate the recordings quality.Main results. The Percept PC reliably recorded the LFP of the implanted site, wirelessly and in real time. We recorded the most promising clinically useful biomarkers for PD and dystonia (beta and theta oscillations) with and without stimulation. Furthermore, we provide an open-source code to facilitate export and analysis of data. Critical aspects of the system are presently related to contact selection, artefact detection, data loss, and synchronization with other devices.Significance. New technologies will soon allow closed-loop neuromodulation therapies, capable of adapting stimulation based on real-time symptom-specific and task-dependent input signals. However, technical aspects need to be considered to ensure reliable recordings. The critical use by a growing number of DBS experts will alert new users about the currently observed shortcomings and inform on how to overcome them.
Keywords
Artifacts, Brain, Deep Brain Stimulation, Humans, Parkinson Disease/diagnosis, Parkinson Disease/therapy, Parkinson’s disease, Percept PC, adaptive deep brain stimulation, artefacts, dystonia, local field potentials
Pubmed
Web of science
Funding(s)
European Commission / 793419
Swiss National Science Foundation / PZ00P3_180018
Create date
04/02/2022 17:02
Last modification date
05/02/2022 6:33
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