Incidence of invasive cancers following carcinoma in situ of the cervix.

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Serval ID
serval:BIB_5310
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Incidence of invasive cancers following carcinoma in situ of the cervix.
Journal
British Journal of Cancer
Author(s)
Levi F., Randimbison L., La Vecchia C., Franceschi S.
ISSN
0007-0920
Publication state
Published
Issued date
1996
Volume
74
Number
8
Pages
1321-1323
Language
english
Abstract
Women with carcinoma in situ (CIS) of the cervix uteri, notified to the population-based Cancer Registry of the Swiss Canton of Vaud between 1974 and 1993, were actively followed up to 31 December 1993 for the occurrence of subsequent invasive neoplasms. Among 2190 incident cases of CIS, followed for a total of 22,225 person-years, 95 metachronous cancers were observed vs 77.9 expected, corresponding to a significant standardised incidence ratio (SIR) of 1.2. Ten cases of invasive cervical cancer were observed vs 3.0 expected (SIR = 3.4, P < 0.01), the excess being larger in the first 10 years since CIS diagnosis. A total of 11 cases of four major tobacco-related sites (lung, mouth or pharynx, oesophagus and urinary bladder) were observed vs 5.1 expected, corresponding to a significant SIR of 2.2. The excess was observed > or = 10 years after CIS diagnosis. There was also an excess of non-melanomatous skin cancers (29 observed, 16.9 expected, SIR = 1.7; P < 0.01), but not of skin melanoma and of any of the other neoplasms considered, including breast and corpus uteri. This population-based study, therefore, finds an excess of invasive cervical cancer in the short term after CIS diagnosis, and a medium- to long-term excess risk of tobacco-related and non-melanomatous skin neoplasms. These findings are discussed in terms of increased surveillance and case ascertainment after CIS, and of potential shared risk factors (tobacco and/or viral infections).
Keywords
Adolescent, Adult, Aged, Aged, 80 and over, Carcinoma in Situ/epidemiology, Carcinoma in Situ/pathology, Child, Child, Preschool, Female, Humans, Incidence, Infant, Infant, Newborn, Middle Aged, Neoplasm Invasiveness, Neoplasms, Second Primary/epidemiology, Neoplasms, Second Primary/pathology, Registries, Skin Neoplasms/epidemiology, Skin Neoplasms/pathology, Smoking/adverse effects, Uterine Cervical Neoplasms/epidemiology, Uterine Cervical Neoplasms/pathology
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Web of science
Create date
19/11/2007 12:41
Last modification date
20/08/2019 14:08
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