Engineering Strategies to Enhance TCR-Based Adoptive T Cell Therapy.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_53031F025A7F
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Engineering Strategies to Enhance TCR-Based Adoptive T Cell Therapy.
Journal
Cells
Author(s)
Rath J.A., Arber C.
ISSN
2073-4409 (Electronic)
ISSN-L
2073-4409
Publication state
Published
Issued date
18/06/2020
Peer-reviewed
Oui
Volume
9
Number
6
Pages
1485
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
T cell receptor (TCR)-based adoptive T cell therapies (ACT) hold great promise for the treatment of cancer, as TCRs can cover a broad range of target antigens. Here we summarize basic, translational and clinical results that provide insight into the challenges and opportunities of TCR-based ACT. We review the characteristics of target antigens and conventional αβ-TCRs, and provide a summary of published clinical trials with TCR-transgenic T cell therapies. We discuss how synthetic biology and innovative engineering strategies are poised to provide solutions for overcoming current limitations, that include functional avidity, MHC restriction, and most importantly, the tumor microenvironment. We also highlight the impact of precision genome editing on the next iteration of TCR-transgenic T cell therapies, and the discovery of novel immune engineering targets. We are convinced that some of these innovations will enable the field to move TCR gene therapy to the next level.
Keywords
CRISPR, adoptive T cell therapy, avidity, cancer immunotherapy, chimeric antigen receptor, chimeric receptors, engineered T cells, gene editing, transgenic TCR, tumor microenvironment
Pubmed
Open Access
Yes
Create date
03/07/2020 19:26
Last modification date
10/03/2021 7:27
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