Influenza vaccine effectiveness in aged individuals: the role played by Cell-mediated immunity.

Details

Serval ID
serval:BIB_52C9C2FE1364
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Influenza vaccine effectiveness in aged individuals: the role played by Cell-mediated immunity.
Journal
European Geriatric Medicine
Author(s)
Lang PO, Govind S, Mitchell WA, Kenny N, Lapenna A, Pitts D, Aspinall R.
ISSN
1878-7649
Publication state
Published
Issued date
09/2010
Peer-reviewed
Oui
Volume
1
Number
4
Pages
233-8
Language
english
Abstract
Older adults are particularly vulnerable to influenza virus, which continues to have a considerable impact worldwide. This is partly due to a waning immune system that attenuates the ability to respond to influenza virus and/or influenza vaccination. According to recent immunogenicity and clinical studies It is becoming increasingly clear that components other than humoral-mediated immunity are required to confer long-term protection in this population. While the level of circulating anti-hemagglutinin antibody is the gold standard used to evaluate influenza vaccine efficacy, T-cell responses appear to be a better correlate of influenza vaccine protection in the elderly population. This review gives further considerations to the age-related changes that influence the immune system's capacity to respond to influenza vaccination, focusing mainly on the impact of cell-mediated immunity, which is the component of the immune system most affected by immunosenescence.
Web of science
Create date
15/04/2015 9:34
Last modification date
20/08/2019 14:08
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