Angioinvasive lymphomatoid papulosis: a new variant simulating aggressive lymphomas.

Details

Serval ID
serval:BIB_529CF746BDF8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Angioinvasive lymphomatoid papulosis: a new variant simulating aggressive lymphomas.
Journal
American Journal of Surgical Pathology
Author(s)
Kempf W., Kazakov D.V., Schärer L., Rütten A., Mentzel T., Paredes B.E., Palmedo G., Panizzon R.G., Kutzner H.
ISSN
1532-0979 (Electronic)
ISSN-L
0147-5185
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
37
Number
1
Pages
1-13
Language
english
Notes
Publication types: Journal Article
Abstract
Lymphomatoid papulosis (LyP) belongs to the spectrum of primary cutaneous CD30-positive lymphoproliferative disorders. Clinically, LyP is characterized by a variable number of self-healing papulo-nodular lesions, with the typical waxing and waning course. Histologically, 4 types (A, B, C, and D) have been delineated. Angioinvasive growth and large ulcers are rare findings in LyP and simulate aggressive lymphoma. We retrospectively analyzed the clinicopathologic and molecular features of angioinvasive LyP in a series of 16 patients. This new form of LyP is characterized by oligolesional papules that rapidly ulcerate and evolve into large necrotic eschar-like lesions with a diameter of 1 to 4 cm and an angiocentric and angiodestructive infiltrate of small-sized to medium-sized atypical lymphocytes expressing CD30 and frequently CD8. As in other forms of LyP, the lesions underwent spontaneous regression after a few weeks. Recurrences were common, but the prognosis was excellent with no extracutaneous spread or disease-related deaths. Complete remission occurred in 9 of 16 patients (56%). This LyP variant should be distinguished from aggressive forms of angiocentric and angiodestructive and cytotoxic T-cell lymphomas. We propose the term LyP type E for this clinically and histologically unusual variant.
Pubmed
Web of science
Create date
17/01/2013 18:10
Last modification date
20/08/2019 14:08
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