Tp63-expressing adult epithelial stem cells cross lineages boundaries revealing latent hairy skin competence.

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License: CC BY 4.0
Serval ID
serval:BIB_526E5DE70293
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Tp63-expressing adult epithelial stem cells cross lineages boundaries revealing latent hairy skin competence.
Journal
Nature communications
Author(s)
Claudinot S., Sakabe J.I., Oshima H., Gonneau C., Mitsiadis T., Littman D., Bonfanti P., Martens G., Nicolas M., Rochat A., Barrandon Y.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
06/11/2020
Peer-reviewed
Oui
Volume
11
Number
1
Pages
5645
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
The formation of hair follicles, a landmark of mammals, requires complex mesenchymal-epithelial interactions and it is commonly believed that embryonic epidermal cells are the only cells that can respond to hair follicle morphogenetic signals in vivo. Here, we demonstrate that epithelial stem cells of non-skin origin (e.g. that of cornea, oesophagus, vagina, bladder, prostate) that express the transcription factor Tp63, a master gene for the development of epidermis and its appendages, can respond to skin morphogenetic signals. When exposed to a newborn skin microenvironment, these cells express hair-follicle lineage markers and contribute to hair follicles, sebaceous glands and/or epidermis renewal. Our results demonstrate that lineage restriction is not immutable and support the notion that all Tp63-expressing epithelial stem cells, independently of their embryonic origin, have latent skin competence explaining why aberrant hair follicles or sebaceous glands are sometimes observed in non-skin tissues (e.g. in cornea, vagina or thymus).
Keywords
Animals, Epidermal Cells/metabolism, Epidermis/growth & development, Epidermis/metabolism, Female, Hair Follicle/metabolism, Humans, Male, Mice, Rats, Stem Cells/metabolism, Trans-Activators/genetics, Trans-Activators/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
22/11/2020 12:30
Last modification date
12/01/2022 8:10
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