Molecular Pathways: Targeting Tumor-Infiltrating Myeloid-Derived Suppressor Cells for Cancer Therapy.

Details

Serval ID
serval:BIB_5265E86D6718
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Molecular Pathways: Targeting Tumor-Infiltrating Myeloid-Derived Suppressor Cells for Cancer Therapy.
Journal
Clinical Cancer Research : An Official Journal of the American Association For Cancer Research
Author(s)
Di Mitri D., Toso A., Alimonti A.
ISSN
1078-0432 (Print)
ISSN-L
1078-0432
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
21
Number
14
Pages
3108-3112
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Tumor-infiltrating myeloid-derived suppressor cells (MDSC) are a heterogeneous and immunosuppressive cell subset that blocks the proliferation and the activity of both T and natural killer (NK) cells and promotes tumor vasculogenesis and progression. Recent evidences demonstrate that the recruitment of MDSCs in tumors also blocks senescence induced by chemotherapy promoting chemoresistance. Hence, the need of novel therapeutic approaches that can efficiently target MDSC recruitment and function in cancer. Among them, novel combinatorial treatments of chemotherapy and immunotherapy or treatments that induce depletion of MDSCs in peripheral sites should be taken in consideration.
Keywords
Animals, Humans, Immune Tolerance/immunology, Myeloid Cells/immunology, Neoplasms/immunology, Tumor Microenvironment/immunology
Pubmed
Web of science
Open Access
Yes
Create date
07/09/2015 15:00
Last modification date
20/08/2019 14:07
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