The contribution of astrocytes to the 18F-2-deoxyglucose signal in PET activation studies

Details

Serval ID
serval:BIB_521AE7071325
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The contribution of astrocytes to the 18F-2-deoxyglucose signal in PET activation studies
Journal
Molecular Psychiatry
Author(s)
Magistretti  P. J., Pellerin  L.
ISSN
1359-4184 (Print)
Publication state
Published
Issued date
12/1996
Volume
1
Number
6
Pages
445-52
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Dec
Abstract
With the development of functional brain imaging techniques such as Positron Emission Tomography (PET) and functional Magnetic Resonance Imaging (fMRI) it has become possible to visualize brain areas that are activated by a variety of sensory, motor or cognitive tasks. This technological progress has permitted a kind of in vivo functional neuroanatomy which has led to the identification of neural circuits subserving specific brain functions. Metabolic processes linked to neuronal activity--such as blood flow, glucose utilization and oxygen consumption--provide the signals detected with most functional brain-imaging techniques. These metabolic indices have been examined in a variety of psychiatric and neurological disorders. This article focuses on the use of (18F)fluoro-2-deoxyglucose (FDG)-PET in the study of psychiatric disorders; it is mainly intended to bring a novel perspective, based on recent experimental data, on the cellular and molecular mechanisms that underlie the FDG-based PET imaging. These new observations point to a critical role of a particular glial cell type, the astrocyte, in coupling neuronal activity to glucose utilization. Indeed it appears that in response to glutamate released by active neurons, glucose is predominantly taken up by specialized astrocytic processes, the end-feet, which surround brain capillaries; glucose is then metabolized to lactate, which provides a preferred energy substrate for neurons. These data support the notion that astrocytes markedly contribute to the FDG-PET signal. This perspective may also provide renewed insights for the interpretation of FDG-PET studies in psychiatric disorders.
Keywords
Astrocytes/*metabolism Brain/cytology/metabolism Deoxyglucose/*diagnostic use Fluorine Radioisotopes/diagnostic use Humans Mental Disorders/*diagnosis Tomography, Emission-Computed/*methods
Pubmed
Web of science
Create date
24/01/2008 13:16
Last modification date
20/08/2019 14:07
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