Validation of the 2018 FIGO Classification for Cervical Cancer: Lymphovascular Space Invasion Should Be Considered in IB1 Stage.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_51E9005D3903
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Validation of the 2018 FIGO Classification for Cervical Cancer: Lymphovascular Space Invasion Should Be Considered in IB1 Stage.
Journal
Cancers
Author(s)
Balaya V., Guani B., Magaud L., Bonsang-Kitzis H., Ngô C., Mathevet P., Lécuru F., On Behalf Of The Senticol Group Group
ISSN
2072-6694 (Print)
ISSN-L
2072-6694
Publication state
Published
Issued date
28/11/2020
Peer-reviewed
Oui
Volume
12
Number
12
Pages
E3554
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
The aim of this study was to assess the prognostic impact of Lymphovascular space invasion (LVSI) in IB1 stage of the revised 2018 International Federation of Gynecology and Obstetrics (FIGO) classification for cervical cancer.
A secondary analysis of two French prospective multicentric trials on Sentinel Lymph node biopsy for cervical cancer was performed. Patients with 2009 FIGO IB1 stage who underwent radical surgery between January 2005 and July 2012 from 28 French expert centers were included. The stage was modified retrospectively according to the new 2018 FIGO staging system.
According to the 2009 FIGO classification, 246 patients had IB1 disease stage and fulfilled the inclusion criteria. The median follow-up was 48 months (4-127). Twenty patients (8.1%) experienced a recurrence, and the 5-year Disease Free Survival (DFS) was 90.0%. Compared to 2018 IB1 staged patients, new IB2 had significantly decreased 5-year DFS, 78.6% vs. 92.9%, p = 0.006 whereas IIIC patients had similar 5-year DFS (91.7%, p = 0.95). In the subgroup of patients with FIGO 2018 IB1 stage, the presence of LVSI was associated with a significant decrease in DFS (82.5% vs. 95.8%, p = 0.04).
LVSI is associated with decreased 5-year DFS in IB1 2018 FIGO stage and LVSI status should be considered in early-stage cervical cancer for a more precise risk assessment.
Keywords
FIGO classification, Lymphovascular space invasion, SENTICOL, cervical cancer, disease-free survival, oncologic outcomes
Pubmed
Web of science
Open Access
Yes
Create date
07/12/2020 15:10
Last modification date
12/01/2022 8:09
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