Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux.

Details

Serval ID
serval:BIB_51AB4869F8C0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux.
Journal
Nature Genetics
Author(s)
Burki F., Kaessmann H.
ISSN
1061-4036[print], 1061-4036[linking]
Publication state
Published
Issued date
2004
Volume
36
Number
10
Pages
1061-1063
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The enzyme glutamate dehydrogenase (GDH) is important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission. Human GDH exists in housekeeping and brain-specific isotypes encoded by the genes GLUD1 and GLUD2, respectively. Here we show that GLUD2 originated by retroposition from GLUD1 in the hominoid ancestor less than 23 million years ago. The amino acid changes responsible for the unique brain-specific properties of the enzyme derived from GLUD2 occurred during a period of positive selection after the duplication event.
Keywords
Animals, Brain/enzymology, Evolution, Molecular, Gene Duplication, Glutamate Dehydrogenase/genetics, Glutamate Dehydrogenase/metabolism, Hominidae/genetics, Hominidae/metabolism, Humans, Isoenzymes/genetics, Isoenzymes/metabolism, Neurotransmitter Agents/metabolism, Phylogeny, Retroelements, Selection, Genetic, Time Factors
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 15:41
Last modification date
20/08/2019 14:07
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