What is the value of hypothermia in acute neurologic diseases and status epilepticus?

Details

Serval ID
serval:BIB_515C8A0CF9AB
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
What is the value of hypothermia in acute neurologic diseases and status epilepticus?
Journal
Epilepsia
Author(s)
Rossetti A.O.
ISSN
1528-1167 (Electronic)
ISSN-L
0013-9580
Publication state
Published
Issued date
2011
Volume
52
Number
Suppl. 8
Pages
64-66
Language
english
Abstract
Patients with status epilepticus that proves refractory to anesthetic agents represent a daunting challenge for treating clinicians. Animal data support the neuroprotective action of brain hypothermia, and its efficacy in status epilepticus models. This approach, targeting a core temperature of about 33°C for at least 24 hours together with pharmacological sedation, has been described in adults and children. However, although relatively safe if concomitant barbiturates are avoided, it seems that mild hypothermia rarely allows a sustained control of ongoing status epilepticus, since seizures tend to recur in normothermia. Conversely, mild hypothermia has a high-evidence level and is increasingly used in postanoxic encephalopathy, both in newborns and adults. Due to the paucity of available clinical data, prospective studies are needed to assess the value of hypothermia in status epilepticus.
Keywords
Animals, Humans, Hypothermia, Induced/methods, Nervous System Diseases/therapy, Status Epilepticus/therapy, Time Factors
Pubmed
Web of science
Create date
17/11/2011 9:47
Last modification date
20/08/2019 14:07
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