Integrated genomic analyses of ovarian carcinoma.

Details

Serval ID
serval:BIB_515951B2EC62
Type
Article: article from journal or magazin.
Collection
Publications
Title
Integrated genomic analyses of ovarian carcinoma.
Journal
Nature
Working group(s)
Cancer Genome Atlas Research Network
Contributor(s)
Bell D., Berchuck A., Birrer M., Chien J., Cramer D., Dao F., Dhir R., DiSaia P., Gabra H., Glenn P., Godwin A., Gross J., Hartmann L., Huang M., Huntsman D., Iacocca M., Imielinski M., Kalloger S., Karlan B., Levine D., Mills G., Morrison C., Mutch D., Olvera N., Orsulic S., Park K., Petrelli N., Rabeno B., Rader J., Sikic B., Smith-McCune K., Sood A., Bowtell D., Penny R., Testa J., Chang K., Dinh H., Drummond J., Fowler G., Gunaratne P., Hawes A., Kovar C., Lewis L., Morgan M., Newsham I., Santibanez J., Reid J., Trevino L., Wu Y-, Wang M., Muzny D., Wheeler D., Gibbs R., Getz G., Lawrence M., Cibulskis K., Sivachenko A., Sougnez C., Voet D., Wilkinson J., Bloom T., Ardlie K., Fennell T., Baldwin J., Gabriel S., Lander E., Ding L.L., Fulton R., Koboldt D., McLellan M., Wylie T., Walker J., O'Laughlin M., Dooling D., Fulton L., Abbott R., Dees N., Zhang Q., Kandoth C., Wendl M., Schierding W., Shen D., Harris C., Schmidt H., Kalicki J., Delehaunty K., Fronick C., Demeter R., Cook L., Wallis J., Lin L., Magrini V., Hodges J., Eldred J., Smith S., Pohl C., Vandin F., Raphael B., Weinstock G., Mardis E., Wilson R., Meyerson M., Winckler W., Getz G., Verhaak R., Carter S., Mermel C., Saksena G., Nguyen H., Onofrio R., Lawrence M., Hubbard D., Gupta S., Crenshaw A., Ramos A., Ardlie K., Chin L., Protopopov A., Zhang J., Kim T., Perna I., Xiao Y., Zhang H., Ren G., Sathiamoorthy N., Park R., Lee E., Park P., Kucherlapati R., Absher M., Waite L., Sherlock G., Brooks J., Li J., Xu J., Myers R., Laird P.W., Cope L., Herman J., Shen H., Weisenberger D., Noushmehr H., Pan F., Triche T., Berman B., Van Den Berg D., Buckley J., Baylin S., Spellman P., Purdom E., Neuvial P., Bengtsson H., Jakkula L., Durinck S., Han J., Dorton S., Marr H., Choi Y., Wang V., Wang N., Ngai J., Conboy J., Parvin B., Feiler H., Speed T., Gray J., Levine A., Socci N., Liang Y., Taylor B., Schultz N., Borsu L., Lash A., Brennan C., Viale A., Sander C., Ladanyi M., Hoadley K., Meng S., Du Y., Shi Y., Li L., Turman Y., Zang D., Helms E., Balu S., Zhou X., Wu J., Topal M., Hayes D., Perou C., Getz G., Voet D., Saksena G., Zhang J., Zhang H., Wu C., Shukla S., Cibulskis K., Lawrence M., Sivachenko A., Jing R., Park R., Liu Y., Park P., Noble M., Chin L., Carter H., Kim D., Karchin R., Spellman P., Purdom E., Neuvial P., Bengtsson H., Durinck S., Han J., Korkola J., Heiser L., Cho R., Hu Z., Parvin B., Speed T., Gray J., Schultz N., Cerami E., Taylor B., Olshen A., Reva B., Antipin Y., Shen R., Mankoo P., Sheridan R., Ciriello G., Chang W., Bernanke J., Borsu L., Levine D., Ladanyi M., Sander C., Haussler D., Benz C., Stuart J., Benz S., Sanborn J., Vaske C., Zhu J., Szeto C., Scott G., Yau C., Hoadley K., Du Y., Balu S., Hayes D., Perou C., Wilkerson M., Zhang N., Akbani R., Baggerly K., Yung W., Mills G., Weinstein J., Penny R., Shelton T., Grimm D., Hatfield M., Morris S., Yena P., Rhodes P., Sherman M., Paulauskis J., Millis S., Kahn A., Greene J., Sfeir R., Jensen M., Chen J., Whitmore J., Alonso S., Jordan J., Chu A., Zhang J., Barker A., Compton C., Eley G., Ferguson M., Fielding P., Gerhard D., Myles R., Schaefer C., Mills Shaw K., Vaught J., Vockley J., Good P., Guyer M., Ozenberger B., Peterson J., Thomson E.
ISSN
1476-4687 (Electronic)
ISSN-L
0028-0836
Publication state
Published
Issued date
29/06/2011
Peer-reviewed
Oui
Volume
474
Number
7353
Pages
609-615
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural
Publication Status: epublish
Abstract
A catalogue of molecular aberrations that cause ovarian cancer is critical for developing and deploying therapies that will improve patients' lives. The Cancer Genome Atlas project has analysed messenger RNA expression, microRNA expression, promoter methylation and DNA copy number in 489 high-grade serous ovarian adenocarcinomas and the DNA sequences of exons from coding genes in 316 of these tumours. Here we report that high-grade serous ovarian cancer is characterized by TP53 mutations in almost all tumours (96%); low prevalence but statistically recurrent somatic mutations in nine further genes including NF1, BRCA1, BRCA2, RB1 and CDK12; 113 significant focal DNA copy number aberrations; and promoter methylation events involving 168 genes. Analyses delineated four ovarian cancer transcriptional subtypes, three microRNA subtypes, four promoter methylation subtypes and a transcriptional signature associated with survival duration, and shed new light on the impact that tumours with BRCA1/2 (BRCA1 or BRCA2) and CCNE1 aberrations have on survival. Pathway analyses suggested that homologous recombination is defective in about half of the tumours analysed, and that NOTCH and FOXM1 signalling are involved in serous ovarian cancer pathophysiology.
Keywords
Aged, Carcinoma/genetics, Carcinoma/physiopathology, DNA Methylation, Female, Gene Dosage, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Genomics, Humans, MicroRNAs/metabolism, Middle Aged, Mutation/genetics, Ovarian Neoplasms/genetics, Ovarian Neoplasms/physiopathology, RNA, Messenger/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
06/07/2018 11:02
Last modification date
21/08/2019 5:34
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