Circadian rhythm of intraocular pressure: a rat model

Details

Serval ID
serval:BIB_513093919654
Type
Article: article from journal or magazin.
Collection
Publications
Title
Circadian rhythm of intraocular pressure: a rat model
Journal
Ophthalmic Research
Author(s)
Krishna  R., Mermoud  A., Baerveldt  G., Minckler  D. S.
ISSN
0030-3747 (Print)
Publication state
Published
Issued date
1995
Volume
27
Number
3
Pages
163-7
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Abstract
The purpose of this study was to examine whether there is a circadian rhythm of intraocular pressure (IOP) in the Lewis rat. Therefore, 20 Lewis rats (40 eyes) were subjected to an alternating 12-hour-light and 12-hour-dark cycle. Using a Tono-Pen 1, IOP was measured every 2 h between 6 a.m. and 12 midnight and every 3 h between 12 midnight and 6 a.m. for 2 consecutive days. These measurements in the Lewis rat revealed a reproducible circadian rhythm with a peak at 8 p.m. and a trough at 6 a.m. In conclusion, when using the Lewis rat as an animal model in longitudinal studies that involve the IOP, the IOP should be measured at the same time each day to correct for diurnal variations. Additionally, Lewis rats may be a useful model to study the causes of circadian rhythms of IOP and for pharmacologic studies of new glaucoma medications.
Keywords
Animals Circadian Rhythm/*physiology Female Intraocular Pressure/*physiology Models, Biological Rats Rats, Inbred Lew Tonometry, Ocular
Pubmed
Web of science
Create date
28/01/2008 13:49
Last modification date
03/03/2018 17:10
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