Plasma renin activity related to sodium balance, renal function and urinary vasopressin in the newborn infant.

Details

Serval ID
serval:BIB_50F7C9859687
Type
Article: article from journal or magazin.
Collection
Publications
Title
Plasma renin activity related to sodium balance, renal function and urinary vasopressin in the newborn infant.
Journal
Pediatric Research
Author(s)
Godard C., Geering J.M., Geering K., Vallotton M.B.
ISSN
0031-3998
Publication state
Published
Issued date
1979
Peer-reviewed
Oui
Volume
13
Number
6
Pages
742-745
Language
english
Abstract
Plasma renin activity was determined in 25 healthy, full-term, newborn infants aged 1 day to 9 weeks. High values were found, the mean level at 1-2 days of life (24.8 +/- 8.4 ng/ml/hr, SE) being significantly higher than the mean levels at 7-9 days (5.8 +/- 1.5) and at 4-9 weeks (8.1 +/- 1.3) (P less than 0.05). No correlation was found between plasma renin activity and systolic blood pressure, hematocrit, creatinine clearance, serum sodium, or serum potassium. Plasma renin activity (log values) was inversely correlated with sodium intake (r = -0.58) or with urinary sodium (r = -0.44), and positively with urinary osmolality (r = 0.67). The correlations reached higher coefficients if only infants aged less than or equal to 9 days were considered. In addition, vasopressin was measured by radioimmunoassay in the urine. The daily excretion was lower in newborn infants (9.4 +/- 1.6 ng/m2/day, SE, at 1-2 days of postnatal life) than in healthy children (37.1 +/- 5.6), and was significantly correlated with creatinine clearance (r = 0.69), but not with urinary osmolality.
Keywords
Blood Pressure, Creatinine/blood, Female, Glomerular Filtration Rate, Humans, Infant, Infant, Newborn, Kidney Function Tests, Male, Potassium/blood, Renin/blood, Sodium/metabolism, Vasopressins/urine
Pubmed
Web of science
Create date
21/02/2008 15:45
Last modification date
20/08/2019 14:06
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