A dramatic lung cancer course in a patient with a rare EGFR germline mutation exon 21 V843I: Is EGFR TKI resistance predictable?

Details

Serval ID
serval:BIB_5082D60AB0F2
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
A dramatic lung cancer course in a patient with a rare EGFR germline mutation exon 21 V843I: Is EGFR TKI resistance predictable?
Journal
Lung Cancer
Author(s)
Demierre N., Zoete V., Michielin O., Stauffer E., Zimmermann D.R., Betticher D.C., Peters S.
ISSN
1872-8332 (Electronic)
ISSN-L
0169-5002
Publication state
Published
Issued date
2013
Volume
80
Number
1
Pages
81-84
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish. PDF type: Case report
Abstract
We report on the medical history of a Caucasian smoker woman diagnosed with a stage IV NSCLC adenocarcinoma, characterized by a rare epidermal growth factor receptor (EGFR) point mutation in exon 21 codon 843 (p.V843I/c.2527G>A/COSMIC ID 85894). This genetic alteration revealed to be germline, after its presence was demonstrated in chondroblasts from the bone biopsy. While it is the first description of germline V843I mutation without concomitant additional known EGFR activating mutation, we modeled the EGFR ATP catalytic domain in complex with ATP, gefitinib and erlotinib using computer-aided approaches to estimate possible changes in affinity upon the V843I mutation.
Pubmed
Web of science
Create date
21/04/2013 9:32
Last modification date
03/03/2018 17:09
Usage data