Manganese intoxication in the rhesus monkey: a clinical, imaging, pathologic, and biochemical study

Details

Serval ID
serval:BIB_504B2B2FFBF9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Manganese intoxication in the rhesus monkey: a clinical, imaging, pathologic, and biochemical study
Journal
Neurology
Author(s)
Olanow  C. W., Good  P. F., Shinotoh  H., Hewitt  K. A., Vingerhoets  F., Snow  B. J., Beal  M. F., Calne  D. B., Perl  D. P.
ISSN
0028-3878 (Print)
Publication state
Published
Issued date
02/1996
Volume
46
Number
2
Pages
492-8
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb
Abstract
We gave three adult rhesus monkeys seven IV injections of manganese chloride at approximately 1-week intervals. We evaluated neurologic status by serial clinical examinations and performed a levodopa test if the animal developed features of basal ganglia dysfunction. After the animals were killed, we performed neuropathologic, neurochemical, and laser microprobe mass analysis (LAMMA) studies. Two of three animals developed a parkinsonian syndrome characterized by bradykinesia, rigidity, and facial grimacing suggestive of dystonia but not tremor. Neither animal responded to levodopa. Autopsy demonstrated gliosis primarily confined to the globus pallidus (GP) and the substantia nigra pars reticularis (SNr). We detected focal mineral deposits throughout the GP and SNr, particularly in a perivascular distribution. LAMMA studies noted that mineral deposits were primarily comprised of iron and aluminum. The severity of pathologic change correlated with the degree of clinical dysfunction. These studies demonstrate that, in contrast to Parkinson's disease (PD) and MPTP-induced parkinsonism, manganese primarily damages the GP and SNr and relatively spares the nigrostriatal dopaminergic system. Further, the results suggest that Mn-induced parkinsonism can be differentiated from PD and MPTP-induced parkinsonism by the clinical syndrome and response to levodopa. The accumulation of iron and aluminum suggests that iron/aluminum-induced oxidant stress may contribute to the damage associated with Mn toxicity.
Keywords
Animals Basal Ganglia/*drug effects/pathology Brain/drug effects/*pathology Carbidopa/pharmacology Chlorides/poisoning/*toxicity Gliosis/pathology Globus Pallidus/drug effects/pathology Levodopa/pharmacology Macaca mulatta Male *Manganese Compounds *Manganese Poisoning Parkinson Disease, Secondary/*chemically induced/pathology/physiopathology Poisoning/pathology Substantia Nigra/drug effects/pathology
Pubmed
Web of science
Create date
25/01/2008 12:49
Last modification date
20/08/2019 14:06
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