Identification of thyroid hormone receptors in the human larynx.

Details

Serval ID
serval:BIB_50197B492378
Type
Article: article from journal or magazin.
Collection
Publications
Title
Identification of thyroid hormone receptors in the human larynx.
Journal
The Laryngoscope
Author(s)
Altman K.W., Haines G.K., Vakkalanka S.K., Keni S.P., Kopp P.A., Radosevich J.A.
ISSN
0023-852X (Print)
ISSN-L
0023-852X
Publication state
Published
Issued date
11/2003
Peer-reviewed
Oui
Volume
113
Number
11
Pages
1931-1934
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Thyroid hormone is essential for normal development, growth, and function of the majority of tissues. Among the many clinical signs associated with hypothyroidism, alterations in the voice may occur even in cases of mild thyroid failure, suggesting that the larynx is a target tissue for thyroid hormone. The objective of our study is to further understand the effects of thyroid hormone on the larynx by first identifying the presence and locations of its receptors.
Two human cadaveric larynges (one male and one female) were harvested, formalin-fixed, and paraffin-embedded. Sections were immunostained with antibodies reactive with the two identified thyroid hormone receptors, TR-alpha and TR-beta. The slides were examined under light microscopy.
Both male and female specimens revealed consistent patterns of staining for thyroid hormone receptors. The staining pattern for TR-alpha included the fibrous connective tissue of the lamina propria, the cartilage, and the glandular elements. The staining pattern for TR-beta included the fibrous connective tissue of the lamina propria only. No receptors were identified in the respiratory mucosa or muscle.
Thyroid hormone receptors are present in both the male and the female human larynx. These findings imply a role for thyroid hormone within the human larynx, through both TR-alpha and TR-beta.
Keywords
Cartilage/cytology, Cartilage/metabolism, Connective Tissue/metabolism, Culture Techniques, Female, Humans, Larynx/cytology, Larynx/metabolism, Male, Muscle, Skeletal/cytology, Muscle, Skeletal/metabolism, Receptors, Thyroid Hormone/metabolism, Respiratory Mucosa/cytology, Respiratory Mucosa/metabolism, Thyroid Gland/cytology, Thyroid Gland/metabolism
Pubmed
Web of science
Create date
30/12/2020 14:43
Last modification date
31/12/2020 6:26
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