Monitoring responses to antiretroviral treatment in human immunodeficiency virus type 1 (HIV-1)-infected patients by serial lymph node aspiration

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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_5016E377940E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Monitoring responses to antiretroviral treatment in human immunodeficiency virus type 1 (HIV-1)-infected patients by serial lymph node aspiration
Journal
Journal of Infectious Diseases
Author(s)
Burgisser  P., Spertini  F., Weyrich-Suter  C., Pagani  J. L., Meylan  P. R.
ISSN
0022-1899 (Print)
Publication state
Published
Issued date
05/1997
Volume
175
Number
5
Pages
1202-5
Language
english
Notes
Clinical Trial
Clinical Trial, Phase III
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: May
Abstract
Fine-needle aspiration was used to collect lymph node cells (LNC) from 9 antiretroviral-naive patients entering a double-blind single- or combined-drug study of zidovudine, zalcitabine, and saquinavir. LNC were obtained twice before and 1 and 6 months after initiation of treatment. The effect of antiretroviral treatment on virus load ranged from no response to a dramatic decrease in plasma and LNC human immunodeficiency virus (HIV) RNA levels. The decrease in unspliced or spliced (or both) HIV RNAs in LNC was correlated with but consistently smaller than the decrease in plasma viremia. When present, the increase in blood CD4 T cells was, in general, moderate and transient. However, a striking rise in blood CD4 T cell count and in LNC CD4:CD8 ratio was observed in the 1 patient with the deepest sustained decrease in HIV RNA level in both plasma and lymph nodes.
Keywords
Acquired Immunodeficiency Syndrome/*drug therapy/immunology/pathology Anti-HIV Agents/*therapeutic use Biopsy, Needle CD4 Lymphocyte Count CD4-CD8 Ratio Double-Blind Method Drug Monitoring/methods Drug Therapy, Combination *HIV-1/genetics/isolation & purification Humans Lymph Nodes/pathology/*virology Polymerase Chain Reaction RNA Splicing RNA, Viral/genetics/isolation & purification Regression Analysis Saquinavir/*therapeutic use Single-Blind Method Viremia/blood Zalcitabine/*therapeutic use Zidovudine/*therapeutic use
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 16:19
Last modification date
25/09/2019 7:09
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