Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation.

Details

Serval ID
serval:BIB_500FADA3B8EC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation.
Journal
Immunity
Author(s)
Yan Y., Jiang W., Spinetti T., Tardivel A., Castillo R., Bourquin C., Guarda G., Tian Z., Tschopp J., Zhou R.
ISSN
1097-4180 (Electronic)
ISSN-L
1074-7613
Publication state
Published
Issued date
2013
Volume
38
Number
6
Pages
1154-1163
Language
english
Abstract
Omega-3 fatty acids (ω-3 FAs) have potential anti-inflammatory activity in a variety of inflammatory human diseases, but the mechanisms remain poorly understood. Here we show that stimulation of macrophages with ω-3 FAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and other family members, abolished NLRP3 inflammasome activation and inhibited subsequent caspase-1 activation and IL-1β secretion. In addition, G protein-coupled receptor 120 (GPR120) and GPR40 and their downstream scaffold protein β-arrestin-2 were shown to be involved in inflammasome inhibition induced by ω-3 FAs. Importantly, ω-3 FAs also prevented NLRP3 inflammasome-dependent inflammation and metabolic disorder in a high-fat-diet-induced type 2 diabetes model. Our results reveal a mechanism through which ω-3 FAs repress inflammation and prevent inflammation-driven diseases and suggest the potential clinical use of ω-3 FAs in gout, autoinflammatory syndromes, or other NLRP3 inflammasome-driven inflammatory diseases.
Keywords
Animals, Arrestins/metabolism, Carrier Proteins/genetics, Carrier Proteins/metabolism, Caspase 1/metabolism, Cells, Cultured, Diabetes Mellitus, Type 2/drug therapy, Diabetes Mellitus, Type 2/etiology, Diet, High-Fat/adverse effects, Docosahexaenoic Acids/pharmacology, Eicosapentaenoic Acid/pharmacology, Enzyme Activation/drug effects, Fatty Acids, Omega-3/immunology, Inflammasomes/immunology, Inflammasomes/metabolism, Inflammation/prevention & control, Interleukin-1beta/metabolism, Macrophages/drug effects, Macrophages/immunology, Mice, Mice, Inbred C57BL, Mice, Knockout, Receptors, G-Protein-Coupled/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
13/12/2013 16:38
Last modification date
20/08/2019 14:06
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