Patterns of evolution of host proteins involved in retroviral pathogenesis.

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Serval ID
serval:BIB_4FD872F6B0FD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Patterns of evolution of host proteins involved in retroviral pathogenesis.
Journal
Retrovirology
Author(s)
Ortiz M., Bleiber G., Martinez R., Kaessmann H., Telenti A.
ISSN
1742-4690[electronic]
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
3
Pages
11
Language
english
Abstract
BACKGROUND: Evolutionary analysis may serve as a useful approach to identify and characterize host defense and viral proteins involved in genetic conflicts. We analyzed patterns of coding sequence evolution of genes with known (TRIM5alpha and APOBEC3G) or suspected (TRIM19/PML) roles in virus restriction, or in viral pathogenesis (PPIA, encoding Cyclophilin A), in the same set of human and non-human primate species. RESULTS AND CONCLUSION: This analysis revealed previously unidentified clusters of positively selected sites in APOBEC3G and TRIM5alpha that may delineate new virus-interaction domains. In contrast, our evolutionary analyses suggest that PPIA is not under diversifying selection in primates, consistent with the interaction of Cyclophilin A being limited to the HIV-1M/SIVcpz lineage. The strong sequence conservation of the TRIM19/PML sequences among primates suggests that this gene does not play a role in antiretroviral defense.
Keywords
Animals, Evolution, Molecular, Genomics, Host-Parasite Interactions, Primates, Proteins, Retroviridae, Selection (Genetics), Simian immunodeficiency virus
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 16:41
Last modification date
20/08/2019 15:05
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