Reactive hyperreninemia is a major determinant of plasma angiotensin II during ACE inhibition.

Details

Serval ID
serval:BIB_4FAC08475B72
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Reactive hyperreninemia is a major determinant of plasma angiotensin II during ACE inhibition.
Journal
Journal of cardiovascular pharmacology
Author(s)
Mooser V., Nussberger J., Juillerat L., Burnier M., Waeber B., Bidiville J., Pauly N., Brunner H.R.
ISSN
0160-2446
Publication state
Published
Issued date
1990
Peer-reviewed
Oui
Volume
15
Number
2
Pages
276-82
Language
english
Notes
Publication types: Clinical Trial ; Journal Article ; Randomized Controlled Trial - Publication Status: ppublish
Abstract
The new ACE inhibitor trandolapril was administered to normal volunteers at daily doses of 0.5, 2, and 8 mg for 10 days. Twenty-one volunteers, aged 21-30 years, were included in the study. To randomly selected groups of seven subjects, each dose was administered in a single-blind fashion. None of the doses induced a consistent fall in blood pressure. Angiotensin-converting enzyme activity (ACE) was measured in vitro using three different synthetic substrates (i.e., Hip-Gly-Gly, Z-Phe-His-Leu, or angiotensin I). Although the degree of ACE inhibition assessed with the three methods varied widely, all methods clearly indicated dose-dependent ACE inhibition. These in vitro results were confirmed by measuring ACE inhibition in vivo using the ratio of plasma angiotensin II (ANG II) to blood angiotensin I (ANG I). The dose-dependent ACE inhibition was paralleled by a dose-dependent rise in active renin and blood angiotensin I levels, most evident on day 10. In contrast, plasma ANG II levels on day 10 were not different whether the volunteers received 0.5 or 8 mg trandolapril. Thus, whereas increasing doses of this new ACE inhibitor progressively enhanced the blockade of ACE activity, this was not reflected by additional reductions of plasma ANG II levels. The progressive enhancement of ACE inhibition seemed to be offset by the accentuation of the compensatory rise in renin and ANG I, which was still partially converted to ANG II.(ABSTRACT TRUNCATED AT 250 WORDS)
Keywords
Adult, Angiotensin I, Angiotensin II, Angiotensin-Converting Enzyme Inhibitors, Blood Pressure, Dose-Response Relationship, Drug, Heart Rate, Humans, Indoles, Iodine Radioisotopes, Renin, Renin-Angiotensin System
Pubmed
Web of science
Create date
25/01/2008 12:55
Last modification date
20/08/2019 14:05
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