Analysis of T cell receptor V alpha polymorphisms in rheumatoid arthritis
Details
Serval ID
serval:BIB_4FA4DDDF3040
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Analysis of T cell receptor V alpha polymorphisms in rheumatoid arthritis
Journal
Annals of the Rheumatic Diseases
ISSN
0003-4967 (Print)
Publication state
Published
Issued date
01/1998
Volume
57
Number
1
Pages
49-51
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan
Research Support, Non-U.S. Gov't --- Old month value: Jan
Abstract
OBJECTIVE: To test for association of T cell receptor (TCR) V alpha polymorphisms and rheumatoid arthritis (RA) in British and Swiss white populations. METHODS: TCRAV polymorphisms were analysed in RA patients and controls by single strand conformational polymorphism (SSCP) analysis. Associations were sought between defined genotypes and RA, and the effect of HLA-DR4 status analysed. Putative associations were then retested further in new groups of patients and controls. Overall, 360 RA patients and 197 controls were studied. RESULTS: No association between TCRAV5S1, V6S1, V8S1, V17S1 or V21S1 polymorphisms and RA were observed in the initial population screened. Stratification for DR4 status showed an increase of V5S1*01/*01 in DR4 positive versus DR4 negative patients (chi 2 = 7.19, p = 0.028 (2df), p = 0.14 after correction for multiple comparisons). This putative association was tested in three further patient groups, none of which showed significant increase of V5S1*01/*01 in DR4 positive patients, although an overall trend towards an increase in V5S1*01/*01 was observed. CONCLUSION: No evidence was found for a strong association of TCRAV genes and RA in a white population. However, these results suggest a weak association of V5S1*01/*01 with DR4 positive RA, although this requires confirmation using larger groups of patients and controls.
Keywords
Arthritis, Rheumatoid/*genetics/immunology
European Continental Ancestry Group
Female
Genes, T-Cell Receptor alpha/*genetics
Genotype
Great Britain
HLA-DR4 Antigen
Humans
Male
Polymerase Chain Reaction
*Polymorphism, Genetic
Polymorphism, Single-Stranded Conformational
Switzerland
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 8:39
Last modification date
20/08/2019 14:05