Inhalation of Microplastics - A Toxicological Complexity.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_4F8367D2B972
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Inhalation of Microplastics - A Toxicological Complexity.
Journal
Toxics
Author(s)
Borgatta M., Breider F.
ISSN
2305-6304 (Electronic)
ISSN-L
2305-6304
Publication state
Published
Issued date
11/05/2024
Peer-reviewed
Oui
Volume
12
Number
5
Language
english
Notes
Publication types: Journal Article - Perspective
Publication Status: epublish
Abstract
Humans are chronically exposed to airborne microplastics (MPs) by inhalation. Various types of polymer particles have been detected in lung samples, which could pose a threat to human health. Inhalation toxicological studies are crucial for assessing the effects of airborne MPs and for exposure-reduction measures. This communication paper addresses important health concerns related to MPs, taking into consideration three levels of complexity, i.e., the particles themselves, the additives present in the plastics, and the exogenous substances adsorbed onto them. This approach aims to obtain a comprehensive toxicological profile of deposited MPs in the lungs, encompassing local and systemic effects. The physicochemical characteristics of MPs may play a pivotal role in lung toxicity. Although evidence suggests toxic effects of MPs in animal and cell models, no established causal link with pulmonary or systemic diseases in humans has been established. The transfer of MPs and associated chemicals from the lungs into the bloodstream and/or pulmonary circulation remains to be confirmed in humans. Understanding the toxicity of MPs requires a multidisciplinary investigation using a One Health approach.
Keywords
human, inhalation, lung, microplastics, toxicity (List three to ten pertinent keywords specific to the article yet reasonably common within the subject discipline.)
Pubmed
Web of science
Open Access
Yes
Create date
27/05/2024 9:23
Last modification date
08/06/2024 6:58
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