Intraepidermal IgA pustulosis preceding a CD30+ anaplastic large T-cell lymphoma

Details

Serval ID
serval:BIB_4F6AD716B3F9
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Intraepidermal IgA pustulosis preceding a CD30+ anaplastic large T-cell lymphoma
Journal
Dermatology
Author(s)
Guggisberg  D., Hohl  D.
ISSN
1018-8665 (Print)
Publication state
Published
Issued date
1995
Volume
191
Number
4
Pages
352-4
Notes
Case Reports
Journal Article
Abstract
We report the case of a 62-year-old patient with an extracutaneous CD30+ anaplastic large T-cell lymphoma which was preceded by intraepidermal IgA pustulosis (IEAP). The clinical picture was identical to Sneddon-Wilkinson disease and histologic examination showed subcorneal pustules with slight acantholysis. Direct immunofluorescence exclusively revealed IgAK deposits on the plasma membrane of suprabasal keratinocytes. Indirect immunofluorescence and immunoelectrophoresis showed no evidence of monoclonal IgA gammopathy. IEAP responded to dapsone treatment (100 mg/day). Two months after disappearance of active cutaneous lesions, the patient developed generalized lymphadenopathy due to CD30+ anaplastic T-cell lymphoma.
Keywords
Acantholysis/pathology Anaplasia Cell Membrane/ultrastructure Dapsone/therapeutic use Epidermis/pathology Fluorescent Antibody Technique, Direct Folic Acid Antagonists/therapeutic use Humans *Immunoglobulin A Immunoglobulin Light Chains Immunoglobulin kappa-Chains Keratinocytes/ultrastructure Lymphoma, Large-Cell, Ki-1/*pathology Male Middle Aged Skin Diseases, Vesiculobullous/drug therapy/*pathology
Pubmed
Web of science
Create date
25/01/2008 16:36
Last modification date
20/08/2019 14:05
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