Mechanisms underlying the health benefits of intermittent hypoxia conditioning.

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Serval ID
serval:BIB_4F68C95D6701
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Mechanisms underlying the health benefits of intermittent hypoxia conditioning.
Journal
The Journal of physiology
Author(s)
Burtscher J., Citherlet T., Camacho-Cardenosa A., Camacho-Cardenosa M., Raberin A., Krumm B., Hohenauer E., Egg M., Lichtblau M., Müller J., Rybnikova E.A., Gatterer H., Debevec T., Baillieul S., Manferdelli G., Behrendt T., Schega L., Ehrenreich H., Millet G.P., Gassmann M., Schwarzer C., Glazachev O., Girard O., Lalande S., Hamlin M., Samaja M., Hüfner K., Burtscher M., Panza G., Mallet R.T.
ISSN
1469-7793 (Electronic)
ISSN-L
0022-3751
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Intermittent hypoxia (IH) is commonly associated with pathological conditions, particularly obstructive sleep apnoea. However, IH is also increasingly used to enhance health and performance and is emerging as a potent non-pharmacological intervention against numerous diseases. Whether IH is detrimental or beneficial for health is largely determined by the intensity, duration, number and frequency of the hypoxic exposures and by the specific responses they engender. Adaptive responses to hypoxia protect from future hypoxic or ischaemic insults, improve cellular resilience and functions, and boost mental and physical performance. The cellular and systemic mechanisms producing these benefits are highly complex, and the failure of different components can shift long-term adaptation to maladaptation and the development of pathologies. Rather than discussing in detail the well-characterized individual responses and adaptations to IH, we here aim to summarize and integrate hypoxia-activated mechanisms into a holistic picture of the body's adaptive responses to hypoxia and specifically IH, and demonstrate how these mechanisms might be mobilized for their health benefits while minimizing the risks of hypoxia exposure.
Keywords
cardiovascular diseases, cellular stress responses, intermittent hypoxia conditioning, mitochondria, neurological disorders, oxygen sensing
Pubmed
Web of science
Open Access
Yes
Create date
06/11/2023 13:48
Last modification date
10/11/2023 7:11
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