Effect on plasma aldosterone, renin activity and cortisol of acute volume depletion induced by ethacrynic acid under constant infusion of angiotensin II and dexamethasone in man

Details

Serval ID
serval:BIB_4F3FCE29089D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effect on plasma aldosterone, renin activity and cortisol of acute volume depletion induced by ethacrynic acid under constant infusion of angiotensin II and dexamethasone in man
Journal
European Journal of Clinical Investigation
Author(s)
Gaillard  R. C., Merkelbach  U., Riondel  A. M., Vallotton  M. B., Muller  A. F.
ISSN
0014-2972 (Print)
Publication state
Published
Issued date
01/1976
Volume
6
Number
1
Pages
51-7
Notes
Clinical Trial
Controlled Clinical Trial
Journal Article --- Old month value: Jan 30
Abstract
The influence on plasma aldosterone of acute volume depletion induced by ethacrynic acid was studied in man. The experiments were performed during the morning in supine healthy males receiving a control infusion of 5% glucose or an infusion of angiotensin II (AII) to suppress endogenous renin production or an infusion of dexamethasone to suppress endogenous ACTH. Ethacrynic acid induced in all circumstances a similar diuresis and volume depletion. The rise of plasma renin activity (PRA) was effectively suppressed by AII and the rise of plasma cortisol by dexamethasone. Plasma aldosterone (PA) rose markedly even when the elevation of PRA or cortisol were suppressed. Yet when both endogenous renin and ACTH secretion were blocked, PA rose much less after ethacrynic acid. This residual increase could be attributed mainly to a decrease of the metabolic clearance rate (MCR) of aldosterone which had been measured before and after ethacrynic acid administration. The data presented indicate that multiple factors influencing PA after acute volume depletion could be dissected out and that renin, ACTH and a decrease of the MCR each contribute to the elevation of PA.
Keywords
Adrenocorticotropic Hormone/physiology Aldosterone/*blood Angiotensin II/*pharmacology Dexamethasone/*pharmacology Ethacrynic Acid/*pharmacology Extracellular Space Humans Hydrocortisone/*blood Male Metabolic Clearance Rate/drug effects Renin/*blood
Pubmed
Web of science
Create date
15/02/2008 16:57
Last modification date
20/08/2019 14:05
Usage data