Immunohistochemical expression of fibronectin and C5b-9 in the myocardium in cases of carbon monoxide poisoning.

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Ressource 1Download: serval:BIB_4F39D9C4ECCE.P001 (539.56 [Ko])
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Serval ID
serval:BIB_4F39D9C4ECCE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Immunohistochemical expression of fibronectin and C5b-9 in the myocardium in cases of carbon monoxide poisoning.
Journal
International Journal of Legal Medicine
Author(s)
Fracasso T., Pfeiffer H., Michaud K., Köhler H., Sauerland C., Schmeling A.
ISSN
1437-1596 (Electronic)
ISSN-L
0937-9827
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
125
Number
3
Pages
377-384
Language
english
Notes
Publication types: Journal Article
Abstract
Even if there is clinical evidence that carbon monoxide poisoning determines cardiac damage, the literature on the cardiac pathomorphology in such cases is scarce. We investigated the immunohistochemical expression of two known markers of fresh cardiac damage, fibronectin and the terminal complement complex C5b-9, in both cardiac ventricles in 26 cases of CO intoxication (study group, 15 ♀, 11 ♂, mean age 47 years, mean COHb level 65.9%, min. 51%, max. 85%) compared to a group of 23 cases of hanging (n = 23, 4♀, 19♂, mean age 42 years) as well as to 25 cases of myocardial infarction (n = 25, 13♀, 12♂, mean age 64 years). Fresh cardiac damage was detected with the antibody fibronectin in cases of CO poisoning and was prevalently localised at the right ventricle.
Keywords
Adult, Biological Markers/analysis, Carbon Monoxide Poisoning/metabolism, Carbon Monoxide Poisoning/pathology, Complement Membrane Attack Complex/metabolism, Female, Fibronectins/metabolism, Humans, Immunohistochemistry, Male, Middle Aged, Myocardial Infarction/diagnosis, Myocardial Infarction/etiology, Myocardium/metabolism, Myocardium/pathology, Necrosis
Pubmed
Web of science
Open Access
Yes
Create date
10/03/2011 16:37
Last modification date
01/10/2019 6:17
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