The Basolateral Amygdala Is Essential for Rapid Escape: A Human and Rodent Study.

Details

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State: Public
Version: Final published version
Serval ID
serval:BIB_4F128B526214
Type
Article: article from journal or magazin.
Collection
Publications
Title
The Basolateral Amygdala Is Essential for Rapid Escape: A Human and Rodent Study.
Journal
Cell
Author(s)
Terburg D., Scheggia D., Triana Del Rio R., Klumpers F., Ciobanu A.C., Morgan B., Montoya E.R., Bos P.A., Giobellina G., van den Burg E.H., de Gelder B., Stein D.J., Stoop R., van Honk J.
ISSN
1097-4172 (Electronic)
ISSN-L
0092-8674
Publication state
Published
Issued date
18/10/2018
Peer-reviewed
Oui
Volume
175
Number
3
Pages
723-735.e16
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Rodent research delineates how the basolateral amygdala (BLA) and central amygdala (CeA) control defensive behaviors, but translation of these findings to humans is needed. Here, we compare humans with natural-selective bilateral BLA lesions to rats with a chemogenetically silenced BLA. We find, across species, an essential role for the BLA in the selection of active escape over passive freezing during exposure to imminent yet escapable threat (T <sub>imm</sub> ). In response to T <sub>imm</sub> , BLA-damaged humans showed increased startle potentiation and BLA-silenced rats demonstrated increased startle potentiation, freezing, and reduced escape behavior as compared to controls. Neuroimaging in humans suggested that the BLA reduces passive defensive responses by inhibiting the brainstem via the CeA. Indeed, T <sub>imm</sub> conditioning potentiated BLA projections onto an inhibitory CeA pathway, and pharmacological activation of this pathway rescued deficient T <sub>imm</sub> responses in BLA-silenced rats. Our data reveal how the BLA, via the CeA, adaptively regulates escape behavior from imminent threat and that this mechanism is evolutionary conserved across rodents and humans.
Keywords
Adult, Animals, Basolateral Nuclear Complex/physiology, Escape Reaction, Fear, Female, Freezing Reaction, Cataleptic, Humans, Male, Rats, Rats, Sprague-Dawley, Reflex, Startle, Species Specificity, DREADD, Urbach Wiethe, basolateral amygdala, central amygdala, escape, fear, freezing, oxytocin, startle reflex, threat
Pubmed
Web of science
Open Access
Yes
Create date
23/10/2018 10:36
Last modification date
20/08/2019 15:04
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