Design and validation of a foldable and photovoltaic wide-field epiretinal prosthesis.

Details

Serval ID
serval:BIB_4EF44BEFF689
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Design and validation of a foldable and photovoltaic wide-field epiretinal prosthesis.
Journal
Nature communications
Author(s)
Ferlauto L., Airaghi Leccardi MJI, Chenais NAL, Gilliéron SCA, Vagni P., Bevilacqua M., Wolfensberger T.J., Sivula K., Ghezzi D.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
08/03/2018
Peer-reviewed
Oui
Volume
9
Number
1
Pages
992
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Retinal prostheses have been developed to fight blindness in people affected by outer retinal layer dystrophies. To date, few hundred patients have received a retinal implant. Inspired by intraocular lenses, we have designed a foldable and photovoltaic wide-field epiretinal prosthesis (named POLYRETINA) capable of stimulating wireless retinal ganglion cells. Here we show that within a visual angle of 46.3 degrees, POLYRETINA embeds 2215 stimulating pixels, of which 967 are in the central area of 5 mm, it is foldable to allow implantation through a small scleral incision, and it has a hemispherical shape to match the curvature of the eye. We demonstrate that it is not cytotoxic and respects optical and thermal safety standards; accelerated ageing shows a lifetime of at least 2 years. POLYRETINA represents significant progress towards the improvement of both visual acuity and visual field with the same device, a current challenging issue in the field.

Keywords
Humans, Prosthesis Design, Prosthesis Implantation/methods, Retina/physiology, Retina/surgery, Visual Acuity/physiology, Visual Prosthesis
Pubmed
Web of science
Open Access
Yes
Create date
15/03/2018 19:22
Last modification date
20/08/2019 14:04
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