Duration of untreated psychosis: a proposition regarding treatment definition.

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State: Public
Version: author
Serval ID
serval:BIB_4EF1BFD37055
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Duration of untreated psychosis: a proposition regarding treatment definition.
Journal
Early Intervention In Psychiatry
Author(s)
Polari A., Lavoie S., Sarrasin P., Pellanda V., Cotton S., Conus P.
ISSN
1751-7893 (Electronic)
ISSN-L
1751-7885
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
5
Number
4
Pages
301-308
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Aim: Duration of untreated psychosis (DUP) refers to the time elapsing between psychosis onset and treatment initiation. Despite a certain degree of consensus regarding the definition of psychosis onset, the definition of treatment commencement varies greatly between studies and DUP may be underestimated due to lack of agreement. In the present study, three sets of criteria to define the end of the untreated period were applied in a first-episode psychosis cohort to assess the impact of the choice of definition on DUP estimation. Methods: The DUP of 117 patients admitted in the Treatment and Early Intervention in Psychosis Program Psychosis in Lausanne was measured using the following sets of criteria to define treatment onset: (i) initiation of antipsychotic medication; (ii) entry into a specialized programme; and (iii) entry into a specialized programme and adequate medication with a good compliance. Results: DUP varied greatly according to definitions, the most restrictive criteria leading to the longest DUP (median DUP1 = 2.2 months, DUP2 = 7.4 months and DUP3 = 13.6 months). A percentage of 19.7 of the patients who did not meet these restrictive criteria had poorer premorbid functioning and were more likely to use cannabis. Longer DUP3 was associated with poorer premorbid functioning and with younger age at onset of psychosis. Conclusion: These results underline the need for a unique and standardized definition of the end of DUP. We suggest that the most restrictive definition of treatment should be used when using the DUP concept in future research.
Pubmed
Web of science
Open Access
Yes
Create date
01/11/2011 10:12
Last modification date
20/08/2019 14:04
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