The hairy and enhancer of split 1 is a negative regulator of the repressor element silencer transcription factor.

Details

Serval ID
serval:BIB_4EEF19605CD1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The hairy and enhancer of split 1 is a negative regulator of the repressor element silencer transcription factor.
Journal
FEBS letters
Author(s)
Abderrahmani A., Niederhauser G., Lenain V., Regazzi R., Waeber G.
ISSN
0014-5793
Publication state
Published
Issued date
2005
Peer-reviewed
Oui
Volume
579
Number
27
Pages
6199-204
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
Silencing of the transcriptional repressor REST is required for terminal differentiation of neuronal and beta-cells. In this study, we hypothesized that REST expression is controlled by hairy and enhancer of split 1 (HES-1), a transcriptional repressor that plays an important role in brain and pancreas development. We identified several N elements (CTNGTG) within the promoter of REST and confirmed that HES-1 associates with the endogenous promoter of REST. Moreover, using a cells model that overexpress HES-1 and a combination of experimental approaches, we demonstrated that HES-1 reduces endogenous REST expression. Taken together, these results indicate that HES-1 is an upstream negative regulator of REST expression.
Keywords
Basic Helix-Loop-Helix Transcription Factors, Down-Regulation, Gene Expression Regulation, Hela Cells, Homeodomain Proteins, Humans, Promoter Regions, Genetic, Repressor Proteins, Response Elements, Transcription Factors
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 14:30
Last modification date
20/08/2019 14:04
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