Fish oil after abdominal aorta aneurysm surgery

Details

Serval ID
serval:BIB_4EE49E8D7DDF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Fish oil after abdominal aorta aneurysm surgery
Journal
European Journal of Clinical Nutrition
Author(s)
Berger M. M., Tappy L., Revelly J. P., Koletzko B. V., Gepert J., Corpataux J. M., Cayeux M. C., Chiolero R. L.
ISSN
0954-3007
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
62
Number
9
Pages
1116-1122
Language
english
Abstract
OBJECTIVE: Fish oil (FO) may attenuate the inflammatory response after major surgery such as abdominal aortic aneurysm (AAA) surgery. We aimed at evaluating the clinical impact and safety aspects of a FO containing parenteral nutrition (PN) after AAA surgery. METHODS: Intervention consisted in 4 days of either standard (STD: Lipofundin medium-chain triglyceride (MCT): long-chain triglyceride (LCT)50%-MCT50%) or FO containing PN (FO: Lipoplus: LCT40%-MCT50%-FO10%). Energy target were set at 1.3 times the preoperative resting energy expenditure by indirect calorimetry. Blood sampling on days 0, 2, 3 and 4. Glucose turnover by the (2)H(2)-glucose method. Muscle microdialysis. Clinical data: maximal daily T degrees, intensive care unit (ICU) and hospital stay. RESULTS: Both solutions were clinically well tolerated, without any differences in laboratory safety parameters, inflammatory, metabolic data, or in organ failures. Plasma tocopherol increased similarly; with FO, docosahexaenoic and eicosapentaenoic acid increased significantly by day 4 versus baseline or STD. To increased postoperatively, with a trend to lower values in FO group (P=0.09). After FO, a trend toward shorter ICU stay (1.6+/-0.4 versus 2.3+/-0.4), and hospital stay (9.9+/-2.4 versus 11.3+/-2.7 days: P=0.19) was observed. CONCLUSIONS: Both lipid emulsions were well tolerated. FO-PN enhanced the plasma n-3 polyunsaturated fatty acid content, and was associated with trends to lower body temperature and shorter length of stay.
Keywords
Aged , Aged,80 and over , Aneurysm , Aortic Aneurysm,Abdominal , blood , Blood Glucose , Body Temperature , Double-Blind Method , Drug Combinations , Emulsions , Female , Fish Oils , Glucose , Humans , Lactates , Length of Stay , Lipids , Male , metabolism , methods , Microdialysis , Middle Aged , Muscle,Skeletal , Parenteral Nutrition , Phospholipids , Plasma , Postoperative Care , Solutions , Sorbitol , surgery , Switzerland , Temperature , therapeutic use , trends
Pubmed
Web of science
Open Access
Yes
Create date
29/01/2009 23:13
Last modification date
20/08/2019 15:04
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