The E. coli multitest: a set of strains to characterize diverse genotoxic effects.

Details

Serval ID
serval:BIB_4EBE42EA68E2
Type
Article: article from journal or magazin.
Collection
Publications
Title
The E. coli multitest: a set of strains to characterize diverse genotoxic effects.
Journal
Mutation Research
Author(s)
Tenenbaum L., Quinto I., Faelen M.
ISSN
0027-5107 (Print)
ISSN-L
0027-5107
Publication state
Published
Issued date
1988
Volume
203
Number
6
Pages
415-426
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
A set of E. coli strains was developed by Toman et al. (1985) to study the effects of chemical and physical agents on forward mutation, homologous recombination and induction of the SOS system. New tester strains have been constructed to improve this test system in order to explore quantitative genotoxicity spectra. Through the use of these strains: (i) SOS induction can be specifically detected without interference from mutagenesis; (ii) SOS-dependent and SOS-independent mutational events can be distinguished; (iii) the sensitivity of the recombination system has been considerably increased.
Keywords
Ampicillin/pharmacology, Bacteriophage lambda/genetics, Cell Membrane Permeability, DNA-Binding Proteins, Escherichia coli/genetics, Gamma Rays, Genetic Engineering, Kanamycin/pharmacology, Methylnitronitrosoguanidine/pharmacology, Mutagenicity Tests/methods, Mutation/drug effects, Mutation/radiation effects, Plasmids, Recombination, Genetic, Repressor Proteins/metabolism, Viral Proteins, Viral Regulatory and Accessory Proteins
Pubmed
Web of science
Create date
01/04/2011 10:17
Last modification date
20/08/2019 14:04
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