Lymphoid Tumours of the Stomach

Details

Serval ID
serval:BIB_4E7C17B22A9C
Type
A part of a book
Publication sub-type
Chapter: chapter ou part
Collection
Publications
Institution
Title
Lymphoid Tumours of the Stomach
Title of the book
Morson and Dawson's Gastrointestinal Pathology
Author(s)
De Leval L.
Publisher
Wiley
ISBN
9781118399668
Publication state
Published
Issued date
2012
Chapter
15
Pages
241-269
Edition
5th ed.
Language
english
Abstract
Primary gastric lymphoma is the second most common tumour of the stomach after adenocarcinoma. Diffuse large B-cell lymphoma (DLBCL) is the most common form of primary gastric lymphoma, closely followed by marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT). Low-grade MALT lymphoma is often multifocal in the stomach, develops in association with Helicobacter pylori infection and is composed of small marginal-zone B cells recapitulating the features of MALT. Eradication of H. pylori leads to complete regression of MALT lymphoma in up to 80% of patients not harbouring the t(11;18) translocation. The differential diagnosis of gastric MALT lymphomas includes reactive lymphoid hyperplasia (H. pylori gastritis) and other small B-cell lymphomas involving the stomach, usually as a secondary manifestation of a systemic disease. Gastric DLBCL occurs anew or as a transformation of t(11;18)-negative MALT lymphoma; it is morphologically similar to nodal DLBCL, but the associated genetic alterations are different. It is primarily treated by polychemotherapy and immunotherapy, supplemented by antibiotics in H. pylori-positive cases. Mantle-cell lymphoma, Burkitt's lymphoma and peripheral T-cell lymphoma represent other, less common, forms of primary gastric lymphoma. Lymphoproliferative disease, arising in a context of immune deficiency, may also present as primary gastric lesions.
Create date
30/09/2016 8:32
Last modification date
20/08/2019 14:04
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